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BioLiP

Structure of PDB 6c1d Chain P Binding Site BS01

Receptor Information
>6c1d Chain P (length=729) Species: 10116 (Rattus norvegicus) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
VKSSLLDNMIGVGDTVLLEPLNEETFIDNLKKRFDHNEIYTYIGSVVISV
NPYRSLPIYSPEKVEDYRNRNFYELSPHIFALSDEAYRSLRDQDKDQCIL
ITGESGAGKTEASKLVMSYVAAVCGKGAEVNQVKEQLLQSTPVLEAFGNA
KTVRNDNSSRFGKYMDIEFDFKGDPLGGVISNYLLEKSRVVKQPRGERNF
HVFYQLLSGASEELLHKLKLERDFSRYNYLSLDSAKVNGVDDAANFRTVR
NAMQIVGFSDPEAESVLEVVAAVLKLGNIEFKPESRMNGLDESKIKDKNE
LKEICELTSIDQVVLERAFSFRTVEAKQEKVSTTLNVAQAYYARDALAKN
LYSRLFSWLVNRINESIKAQTKVRKKVMGVLDIYGFEIFEDNSFEQFIIN
YCNEKLQQIFIELTLKEEQEEYIREDIEWTHIDYFNNAIICDLIENNTNG
ILAMLDEECLRPGTVTDETFLEKLNQVCATHQHFESRMSKCSRFLNDTTL
PHSCFRIQHYAGKVLYQVEGFVDKNNDLLYRDLSQAMWKAGHALIKSLFP
EGNPAKVNLKRPPTAGSQFKASVATLMKNLQTKNPNYIRCIKPNDKKAAH
IFSESLVCHQIRYLGLLENVRVRRAGYAFRQAYEPCLERYKMLCKQTWPH
WKGPARSGVEVLFNELEIPVEEYSFGRSKIFIRNPRTLFQLEDLRKQRLE
DLATLIQKIYRGWKCRTHFLLMKGLNDIF
Ligand information
Ligand IDADP
InChIInChI=1S/C10H15N5O10P2/c11-8-5-9(13-2-12-8)15(3-14-5)10-7(17)6(16)4(24-10)1-23-27(21,22)25-26(18,19)20/h2-4,6-7,10,16-17H,1H2,(H,21,22)(H2,11,12,13)(H2,18,19,20)/t4-,6-,7-,10-/m1/s1
InChIKeyXTWYTFMLZFPYCI-KQYNXXCUSA-N
SMILES
SoftwareSMILES
OpenEye OEToolkits 1.5.0c1nc(c2c(n1)n(cn2)[C@H]3[C@@H]([C@@H]([C@H](O3)CO[P@](=O)(O)OP(=O)(O)O)O)O)N
CACTVS 3.341Nc1ncnc2n(cnc12)[CH]3O[CH](CO[P](O)(=O)O[P](O)(O)=O)[CH](O)[CH]3O
ACDLabs 10.04O=P(O)(O)OP(=O)(O)OCC3OC(n2cnc1c(ncnc12)N)C(O)C3O
CACTVS 3.341Nc1ncnc2n(cnc12)[C@@H]3O[C@H](CO[P@@](O)(=O)O[P](O)(O)=O)[C@@H](O)[C@H]3O
OpenEye OEToolkits 1.5.0c1nc(c2c(n1)n(cn2)C3C(C(C(O3)COP(=O)(O)OP(=O)(O)O)O)O)N
FormulaC10 H15 N5 O10 P2
NameADENOSINE-5'-DIPHOSPHATE
ChEMBLCHEMBL14830
DrugBankDB16833
ZINCZINC000012360703
PDB chain6c1d Chain P Residue 802 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB6c1d High-resolution cryo-EM structures of actin-bound myosin states reveal the mechanism of myosin force sensing.
Resolution3.2 Å
Binding residue
(original residue number in PDB)		N56 P57 G111 G113 K114 T115 E116
Binding residue
(residue number reindexed from 1)		N51 P52 G106 G108 K109 T110 E111
Annotation score4
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0003774 cytoskeletal motor activity
GO:0005524 ATP binding
Cellular Component
GO:0016459 myosin complex

View graph for
Molecular Function
View graph for
Cellular Component
External links
PDB RCSB:6c1d, PDBe:6c1d, PDBj:6c1d
PDBsum6c1d
PubMed29358376
UniProtQ05096|MYO1B_RAT Unconventional myosin-Ib (Gene Name=Myo1b)

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