BioLiP

Structure of PDB 7r4g Chain N Binding Site BS01

Receptor Information

>7r4g Chain N (length=347) Species: 9913 (Bos taurus) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]

MNPIIFIIILLTIMLGTIIVMISSHWLLVWIGFEMNMLAIIPIMMKNHNP
RATEASTKYFLTQSTASMLLMMAVIINLMFSGQWTVMKLFNPMASMLMTM
ALAMKLGMAPFHFWVPEVTQGIPLSSGLILLTWQKLAPMSVLYQIFPSIN
LNLILTLSVLSILIGGWGGLNQTQLRKIMAYSSIAHMGWMTAVLPYNPTM
TLLNLIIYIIMTSTMFTMFMANSTTTTLSLSHTWNKTPIMTVLILATLLS
MGGLPPLSGFMPKWMIIQEMTKNNSIILPTFMAITALLNLYFYMRLTYST
TLTMFPSTNNMKMKWQFPLMKKMTFLPTMVVLSTMMLPLTPMLSVLE

Ligand information

>7r4g Chain Y (length=20) Species: 9913 (Bos taurus) [Search peptide sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]

AALVKMGQLEGWQVFAEPKV

Receptor-Ligand Complex Structure

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Structure summary

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PDB	7r4g Structural basis of mammalian respiratory complex I inhibition by medicinal biguanides.
Resolution	2.5 Å
Binding residue (original residue number in PDB)	L151 Y196 N273
Binding residue (residue number reindexed from 1)	L151 Y196 N273

Enzymatic activity

Enzyme Commision number

7.1.1.2: NADH:ubiquinone reductase (H(+)-translocating).

Gene Ontology

	Molecular Function
GO:0008137	NADH dehydrogenase (ubiquinone) activity

	Biological Process
GO:0006120	mitochondrial electron transport, NADH to ubiquinone
GO:0032981	mitochondrial respiratory chain complex I assembly
GO:1902600	proton transmembrane transport

	Cellular Component
GO:0005739	mitochondrion
GO:0005743	mitochondrial inner membrane
GO:0045271	respiratory chain complex I

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PDB	RCSB:7r4g, PDBe:7r4g, PDBj:7r4g
PDBsum	7r4g
PubMed	36701435
UniProt	P03892\|NU2M_BOVIN NADH-ubiquinone oxidoreductase chain 2 (Gene Name=MT-ND2)