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BioLiP

Structure of PDB 7r4g Chain M Binding Site BS01

Receptor Information
>7r4g Chain M (length=459) Species: 9913 (Bos taurus) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
MLKYIIPTIMLMPLTWLSKNNMIWVNSTAHSLLISFTSLLLMNQFGDNSL
NFSLLFFSDSLSTPLLILTMWLLPLMLMASQHHLSKENLTRKKLFITMLI
SLQLFLIMTFTAMELILFYILFEATLVPTLIIITRWGNQTERLNAGLYFL
FYTLAGSLPLLVALIYIQNTVGSLNFLMLQYWVQPVHNSWSNVFMWLACM
MAFMVKMPLYGLHLWLPKAHVEAPIAGSMVLAAVLLKLGGYGMLRITLIL
NPMTDFMAYPFIMLSLWGMIMTSSICLRQTDLKSLIAYSSVSHMALVIVA
ILIQTPWSYMGATALMIAHGLTSSMLFCLANSNYERIHSRTMILARGLQT
LLPLMATWWLLASLTNLALPPTINLIGELFVVMSTFSWSNITIILMGVNM
VITALYSLYMLIMTQRGKYTYHINNISPSFTRENALMSLHILPLLLLTLN
PKIILGPLY
Ligand information
Receptor-Ligand Complex Structure
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PDB7r4g Structural basis of mammalian respiratory complex I inhibition by medicinal biguanides.
Resolution2.5 Å
Binding residue
(original residue number in PDB)		S189 W190 S191 F194
Binding residue
(residue number reindexed from 1)		S189 W190 S191 F194
Enzymatic activity
Enzyme Commision number 7.1.1.2: NADH:ubiquinone reductase (H(+)-translocating).
Gene Ontology
Molecular Function
GO:0003954 NADH dehydrogenase activity
GO:0008137 NADH dehydrogenase (ubiquinone) activity
GO:0048039 ubiquinone binding
Biological Process
GO:0006120 mitochondrial electron transport, NADH to ubiquinone
GO:0009060 aerobic respiration
GO:0015990 electron transport coupled proton transport
GO:0032981 mitochondrial respiratory chain complex I assembly
GO:0042773 ATP synthesis coupled electron transport
Cellular Component
GO:0005739 mitochondrion
GO:0005743 mitochondrial inner membrane
GO:0045271 respiratory chain complex I

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:7r4g, PDBe:7r4g, PDBj:7r4g
PDBsum7r4g
PubMed36701435
UniProtP03910|NU4M_BOVIN NADH-ubiquinone oxidoreductase chain 4 (Gene Name=MT-ND4)

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