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Structure of PDB 8xt0 Chain LW Binding Site BS01

Receptor Information
>8xt0 Chain LW (length=143) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
MARNVVYPLYRLGGPQLRVFRTNFFIQLVRPGVAQPEDTVQFRIPMEMTR
VDLRNYLEGIYNVPVAAVRTRVQHGSNKRRDHRNVRIKKPDYKVAYVQLA
HGQTFTFPDLFPEDDLYSMLEEERQQRQSSDPRRGGVPSWFGL
Ligand information
>8xt0 Chain L1 (length=1500) [Search RNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
gcuaaaccuagccccaaacccacuccaccuuacuaccagacaaccuuagc
caaaccauuuacccaaauaaaguauaggcgauagaaauugacuggcgcaa
uagauauaguaccgcaagggaaagaugaaaaauuauaaccaagcauaaua
uagcaaggacuaaccccuauaccuucugcauaaugaauuaacuagaaaua
acuuugcaaggagagccaaagcuaagacccccgaaaccagacgagcuacc
uaagaacagcuaaaagagcacacccgucuauguagcaaaauagugggaag
auuuauagguagaggcgacaaaccuaccgagccuggugauagcugguugu
ccaagauagaaucuuaguucaacuuuaaauuugcccacagaaccaaaucc
ccuuguaaauuuaacuguuaguccaaagaggaacagcucuuuggacacua
ggaaaaaaccuuguagagagaguaaaaaauuuaacacccauaguaggccu
aaaagcagccaccaauuaagaaagcguucaagcucaacacccacuaccua
aaaaaucccaaacauauaacugaacuccucacacccaauuggaccaaucu
aucacccuauagaagaacuaauguuaguauaaguaacaugaaaacauucu
ccuccgcauaagccugcgucagaucacacugacaauuaacagcccaauau
cuacaaucaaccaacaagucauuauuacccucacugucaacccaacacag
gcaugcucauaaggaaagguuaaaaaaaguaaaaggaacucggcaaaucu
uaccccgccuguuuaccaaaaacaucaccucuagcaucaccaguauuaga
ggcaccgccugcccagugacacauguuuaacggccgcgguacccuaaccg
ugcaaagguagcauaaucacuuguuccuuaaauagggaccuguaugaaug
gcuccacgaggguucagcugucucuuacuuuuaaccagugaaauugaccu
gcccgugaagaggcgggcauaacacagcaagacgagaagacccuauggag
cuuuaauuuauuaaugcaaacaguaaccugcauuaaaaauuucgguuggg
gcgaccucggagcagaacccaaccuccgagcaguacaugcuaagacuuca
ccagucaaagcgaaccucaauugauccaauaacuugaccaacggaacaag
uuacccuagggauaacagcgcaauccuauucuagaguccauaucaacaau
aggguuuacgaccucgauguuggaucaggacaucccgauggugcagccgc
uauuaaagguucguuuguucaacgauuaaaguccuacgugaucugaguuc
agaccggaguaauccaggucgguuucuaucuacuuuaaauuccucccugu
acgaaaggacaagagaaauaaggccuacuucacaaagcgccuucccccgu
aaaugauaucaucucaacuuagauacccacacccacccaagaacaggguu
<<<.......<<<<....................................
.<......>...............<<.....>>..........>>.>>..
...........<<....>>......................>>>......
.....<<<.......>>>...<.<........>.>.<<<<<<........
.<<<.<<..<<....>>...>>.>>>...<<.<...<<<<.<.....<<<
<<.<<<..<<<.....>>>...<<<..<<<<........>>>>.>>>...
.>>>.>>>>>...<<.......>>......>.>>>>......>.>>..<<
<<<<....<<<<....>>>><<<.<<<<<<<<<<.....<<......>>.
....>>>>>>>>>>..>>>.<<<<<<<<<<......>>>>>>>>>>...<
<<......>>>....<<<.<<<...<..............<....<<<..
.......>>>....>.......<<<......>>>................
....................>...>>>>>>........>>>>>>...<<<
<<......>>>>>.........>>>>>><......<<..<<<....>>><
<<<..<<<<........<<<<<......>>>>>......<<<...<<<<.
......................>>>>.......>>>.....<<......>
>.>>>>.....>>>>..<<<<...<<<<<<<<.<<.........<.....
.<<<<<<..<<<.........>>>...<<<<<<.............>>>>
>>....<<<.<<<..<<<<<....>>>..>>>>><<<<<<......>>>>
>>........<...........<<<<<<.....>>>>>>.....>....>
>>....>>.>>>>.....>..>>.>>>>>>>>>>>>.>>.....>.....
<<<<<........>>>>>.......<<..<<<.<<......<<<<.<<<<
<<..<<<<<.<<<<<<<<..........>>>>>>>>>>>>>..<<<<...
..>>>><<<<<<...........>>>>>>..<<.....<<<..<<<<...
..>>>>..>>>....>>.........<<<....>>>............>>
>>..>>>>>>.......<<<..<.<<<<<<...<<.......>>...>>>
>>>...>.>>.>.......<<<<<.<<<<<<..<<.<<<<<<......>>
>>>>...>>.<<<<<.....>>>>>.....>>>>>..>...>>>.>>...
.<<<<<<<....>>>.>>>>....>>..>>>.>>....<<<.<<<.....
............>>>.>>><<<<<...<<<....>>>.>>>>>......<
<<................>>>.............<<<<.......>>>>.
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB8xt0 Structural basis for differential inhibition of eukaryotic ribosomes by tigecycline.
Resolution3.2 Å
Binding residue
(original residue number in PDB)		N4 V6 L9 P31 G32 Q41 R43 T49 R50 V51 R69 T70 R71 V72 Q73 H74 S76 K78 R79 R80 R83 N84 K93 Y96
Binding residue
(residue number reindexed from 1)		N4 V6 L9 P31 G32 Q41 R43 T49 R50 V51 R69 T70 R71 V72 Q73 H74 S76 K78 R79 R80 R83 N84 K93 Y96
Gene Ontology
Molecular Function
GO:0003723 RNA binding
GO:0003735 structural constituent of ribosome
GO:0005515 protein binding
Biological Process
GO:0006412 translation
GO:0032543 mitochondrial translation
Cellular Component
GO:0001650 fibrillar center
GO:0005739 mitochondrion
GO:0005743 mitochondrial inner membrane
GO:0005762 mitochondrial large ribosomal subunit
GO:0005840 ribosome
GO:0044391 ribosomal subunit
GO:1990904 ribonucleoprotein complex

View graph for
Molecular Function
View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:8xt0, PDBe:8xt0, PDBj:8xt0
PDBsum8xt0
PubMed38942792
UniProtQ16540|RM23_HUMAN Large ribosomal subunit protein uL23m (Gene Name=MRPL23)

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