Structure of PDB 4kze Chain H Binding Site BS01
Receptor Information
>4kze Chain H (length=225) Species:
10090
(Mus musculus) [
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EVQLVESGGGLVQPGGSLRLSCAASGFYISYSSIHWVRQAPGKGLEWVAS
ISPYSGSTYYADSVKGRFTISADTSKNTAYLQMNSLRAEDTAVYYCARQG
YRRRSGRGFDYWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCL
VKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGT
QTYICNVNHKPSNTKVDKKVEPKSC
Ligand information
>4kze Chain R (length=84) [
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ggacgcgaccgaaauggugaaggacggguccagugcgaaacacgcacugu
ugaguagagugugagcuccguaacuggucgcguc
.<<<<<<<<<<..<<<<...........<.<<<<<<<.....>>>>>>>.
..>..............>>>>..>.>>>>>>>>>
Receptor-Ligand Complex Structure
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PDB
4kze
A G-quadruplex-containing RNA activates fluorescence in a GFP-like fluorophore.
Resolution
2.404 Å
Binding residue
(original residue number in PDB)
Y34 P56 Y57 S58 S60 Y62 Q102 Y104 R105 R110
Binding residue
(residue number reindexed from 1)
Y31 P53 Y54 S55 S57 Y59 Q99 Y101 R102 R107
Binding affinity
PDBbind-CN
: Kd=25nM
External links
PDB
RCSB:4kze
,
PDBe:4kze
,
PDBj:4kze
PDBsum
4kze
PubMed
24952597
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