Home Research COVID-19 Services Publications People Teaching Job Opening News Forum Lab Only

Online Services

●I-TASSER ●I-TASSER-MTD ●C-I-TASSER ●CR-I-TASSER ●QUARK ●C-QUARK ●LOMETS ●MUSTER ●CEthreader ●SEGMER ●DeepFold ●DeepFoldRNA ●FoldDesign ●COFACTOR ●COACH ●MetaGO ●TripletGO ●IonCom ●FG-MD ●ModRefiner ●REMO ●DEMO ●DEMO-EM ●SPRING ●COTH ●Threpp ●PEPPI ●BSpred ●ANGLOR ●EDock ●BSP-SLIM ●SAXSTER ●FUpred ●ThreaDom ●ThreaDomEx ●EvoDesign ●BindProf ●BindProfX ●SSIPe ●GPCR-I-TASSER ●MAGELLAN ●ResQ ●STRUM ●DAMpred

●TM-score ●TM-align ●US-align ●MM-align ●RNA-align ●NW-align ●LS-align ●EDTSurf ●MVP ●MVP-Fit ●SPICKER ●HAAD ●PSSpred ●3DRobot ●MR-REX ●I-TASSER-MR ●SVMSEQ ●NeBcon ●ResPRE ●TripletRes ●DeepPotential ●WDL-RF ●ATPbind ●DockRMSD ●DeepMSA ●FASPR ●EM-Refiner ●GPU-I-TASSER

●BioLiP ●E. coli ●GLASS ●GPCR-HGmod ●GPCR-RD ●GPCR-EXP ●Tara-3D ●TM-fold ●DECOYS ●POTENTIAL ●RW/RWplus ●EvoEF ●HPSF ●THE-DB ●ADDRESS ●Alpaca-Antibody ●CASP7 ●CASP8 ●CASP9 ●CASP10 ●CASP11 ●CASP12 ●CASP13 ●CASP14

Structure of PDB 6i5p Chain G Binding Site BS01

Receptor Information

>6i5p Chain G (length=140) Species: 9606 (Homo sapiens)

GKVVKFSYMWTINNFSFCREKMGEVIKSSTFSSGANDKLKWCLRVNPKGL
DEESKDYLSLYLLLVSCPKSEVRAKFKFSILNAKGEETKAMESQRAYRFV
QGKDWGFKKFIRRDFLLDEANGLLPDDKLTLFCEVSVVQD

Ligand information

>6i5p Chain H (length=7) Species: 9606 (Homo sapiens)

KADTTTP

Receptor-Ligand Complex Structure

Structure summary

• PDB: 6i5p Structural Insights into BET Client Recognition of Endometrial and Prostate Cancer-Associated SPOP Mutants.
• Resolution: 1.81 Å
• Binding residue (original residue number in PDB): Y87 Y123 K129 D130 W131 G132 F133
• Binding residue (residue number reindexed from 1): Y61 Y97 K103 D104 W105 G106 F107

External links

• PDB: RCSB:6i5p, PDBe:6i5p, PDBj:6i5p
• PDBsum: 6i5p
• PubMed: 31026449
• UniProt: O43791|SPOP_HUMAN Speckle-type POZ protein (Gene Name=SPOP)

zhanglabzhanggroup.org | +65-6601-1241 | Computing 1, 13 Computing Drive, Singapore 117417