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BioLiP

Structure of PDB 8xhk Chain E Binding Site BS01

Receptor Information
>8xhk Chain E (length=391) Species: 1093098 (Streptomyces albogriseolus 1-36) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
LRHLSDGYWDSAARLGVHGAVLQAVPGGRLSAPDGRVAVNMSSYSYLGLD
ESPRIIDAAIAALRSNMVLNSSLGRVRMTLPLLEEAECALGDLFGADVAT
LNSCSAAAWATLPVLASGLLTDGVAPVMVFDKRAHFCMASLKSLCADETR
VETIRHNDVDALADICRKNKRVAYVCDSVYSTGGTLAPLEELFALQKEFG
LFLYFDEAHSTSVIGDMGRGYVLDRMGAINDSTMLITSLNKGFGASGGAI
VFGPRDDDRKRKIIQRSSGPLMWSQRLNTPALGAIIESAKLHRSEALPEL
QAKLHSNIALFDGLVRAAGQGNSVPIRYLELGSEVDTLEASAYLFDNGFY
VEPDFFPIVSRGAAGLRARIRSSMSTADIEQFAHVWHKLGV
Ligand information
Ligand IDPLP
InChIInChI=1S/C8H10NO6P/c1-5-8(11)7(3-10)6(2-9-5)4-15-16(12,13)14/h2-3,11H,4H2,1H3,(H2,12,13,14)
InChIKeyNGVDGCNFYWLIFO-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.341Cc1ncc(CO[P](O)(O)=O)c(C=O)c1O
OpenEye OEToolkits 1.5.0Cc1c(c(c(cn1)COP(=O)(O)O)C=O)O
ACDLabs 10.04O=P(O)(O)OCc1cnc(c(O)c1C=O)C
FormulaC8 H10 N O6 P
NamePYRIDOXAL-5'-PHOSPHATE;
VITAMIN B6 Phosphate
ChEMBLCHEMBL82202
DrugBankDB00114
ZINCZINC000001532514
PDB chain8xhk Chain B Residue 501 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB8xhk Structural and mechanistic investigations on CC bond forming alpha-oxoamine synthase allowing L-glutamate as substrate.
Resolution2.79 Å
Binding residue
(original residue number in PDB)		R88 S287 Q288
Binding residue
(residue number reindexed from 1)		R75 S274 Q275
Annotation score1
Enzymatic activity
Enzyme Commision number 2.3.1.47: 8-amino-7-oxononanoate synthase.
Gene Ontology
Molecular Function
GO:0008483 transaminase activity
GO:0030170 pyridoxal phosphate binding
Biological Process
GO:0009058 biosynthetic process

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Molecular Function
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Biological Process
External links

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