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BioLiP

Structure of PDB 5b4w Chain E Binding Site BS01

Receptor Information
>5b4w Chain E (length=478) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
TAFTPNGTYLQHLARDPTSGTLYLGATNFLFQLSPGLQLEATVSTGPVLD
SRDCLPPVMPDECPQAQPTNNPNQLLLVSPGALVVCGSVHQGVCEQRRLG
QLEQLLLRPERPGDTQYVAANDPAVSTVGLVAQGLAGEPLLFVGRGYTSR
GGIPPITTRALWPPDPQAAFSYEETAKLAVGRLSEYSHHFVSAFARGASA
YFLFLRRDLQAQSRAFRAYVSRVCLRDQHYYSYVELPLACEGGRYGLIQA
AAVATSREVAHGEVLFAAFSSAGASALCAFPLDEVDRLANRTRDACYTRE
GRAEDGTEVAYIEYDVNSDCAQLPVDTLDAYPCGSDHTPSPMASRVPLEA
TPILEWPGIQLTAVAVTMEDGHTIAFLGDSQGQLHRVYLGPGSDGHPYST
QSIQQGSAVSRDLTFDGTFEHLYVMTQSTLLKVPVASCAQHLDCASCLAH
RDPYCGWCVLLGRCSRRSECSQWLWSFQ
Ligand information
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB5b4w Allosteric Inhibition of a Semaphorin 4D Receptor Plexin B1 by a High-Affinity Macrocyclic Peptide
Resolution2.6 Å
Binding residue
(original residue number in PDB)		V292 F294 T395 P396 I397 E399 D414 G415 H416 T417 L433 G434 P435 S437
Binding residue
(residue number reindexed from 1)		V264 F266 T351 P352 I353 E355 D370 G371 H372 T373 L389 G390 P391 S393
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0017154 semaphorin receptor activity
Biological Process
GO:0071526 semaphorin-plexin signaling pathway

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Molecular Function
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Biological Process
External links
PDB RCSB:5b4w, PDBe:5b4w, PDBj:5b4w
PDBsum5b4w
PubMed27984026
UniProtO43157|PLXB1_HUMAN Plexin-B1 (Gene Name=PLXNB1)

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