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BioLiP

Structure of PDB 3ecs Chain E Binding Site BS01

Receptor Information
>3ecs Chain E (length=285) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
MDDKELIEYFKSQMKEDPDMASAVAAIRTLLEFLKRDETIQGLRANLTSA
IETLCGVDSSVAVSSGGELFLRFISLSKCKKIMIERGELFLRRISLSRNK
IADLCHTFIKDGATILTHAYSRVVLRVLEAAVAAKKRFSVYVTESQPDLS
GKKMAKALCHLNVPVTVVLDAAVGYIMEKADLVIVGAEGVVENGGIINKI
GTNQMAVCAKAQNKPFYVVAESFKFVRLFPLNQQDVPDKFKYDLKEEHPW
VDYTAPSLITLLFTDLGVLTPSAVSDELIKLYLAA
Ligand information
Ligand IDSO4
InChIInChI=1S/H2O4S/c1-5(2,3)4/h(H2,1,2,3,4)/p-2
InChIKeyQAOWNCQODCNURD-UHFFFAOYSA-L
SMILES
SoftwareSMILES
OpenEye OEToolkits 1.5.0[O-]S(=O)(=O)[O-]
CACTVS 3.341[O-][S]([O-])(=O)=O
ACDLabs 10.04[O-]S([O-])(=O)=O
FormulaO4 S
NameSULFATE ION
ChEMBL
DrugBankDB14546
ZINC
PDB chain3ecs Chain E Residue 505 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB3ecs Crystal structure of the alpha subunit of human translation initiation factor 2B
Resolution2.65 Å
Binding residue
(original residue number in PDB)		S131 R132 K234
Binding residue
(residue number reindexed from 1)		S121 R122 K224
Annotation score3
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0003743 translation initiation factor activity
GO:0005085 guanyl-nucleotide exchange factor activity
GO:0005515 protein binding
GO:0042802 identical protein binding
Biological Process
GO:0002183 cytoplasmic translational initiation
GO:0006412 translation
GO:0006413 translational initiation
GO:0009408 response to heat
GO:0009749 response to glucose
GO:0014003 oligodendrocyte development
GO:0043434 response to peptide hormone
GO:0044237 cellular metabolic process
GO:0050852 T cell receptor signaling pathway
Cellular Component
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0005851 eukaryotic translation initiation factor 2B complex
GO:0005886 plasma membrane
GO:0016020 membrane

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:3ecs, PDBe:3ecs, PDBj:3ecs
PDBsum3ecs
PubMed19631657
UniProtQ14232|EI2BA_HUMAN Translation initiation factor eIF2B subunit alpha (Gene Name=EIF2B1)

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