Structure of PDB 1h15 Chain E Binding Site BS01

Receptor Information
>1h15 Chain E (length=189) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
DTRPRFLQQDKYECHFFNGTERVRFLHRDIYNQEEDLRFDSDVGEYRAVT
ELGRPDAEYWNSQKDFLEDRRAAVDTYCRHNYGVGESFTVQRRVEPKVTV
YPARTQTLQHHNLLVCSVNGFYPGSIEVRWFRNSQEEKAGVVSTGLIQNG
DWTFQTLVMLETVPRSGEVYTCQVEHPSVTSPLTVEWRA
Ligand information
>1h15 Chain F (length=14) Species: 10376 (human gammaherpesvirus 4) [Search peptide sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
GGVYHFVKKHVHES
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB1h15 A Functional and Structural Basis for Tcr Cross-Reactivity in Multiple Sclerosis
Resolution3.1 Å
Binding residue
(original residue number in PDB)		D11 Y13 Y60 W61 F67 R71 T77 Y78 H81 N82 V85
Binding residue
(residue number reindexed from 1)		D10 Y12 Y59 W60 F66 R70 T76 Y77 H80 N81 V84
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Biological Process
GO:0006955 immune response
GO:0019882 antigen processing and presentation
Cellular Component
GO:0016020 membrane
GO:0042613 MHC class II protein complex

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Biological Process
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Cellular Component
External links
PDB RCSB:1h15, PDBe:1h15, PDBj:1h15
PDBsum1h15
PubMed12244309
UniProtQ30154|DRB5_HUMAN HLA class II histocompatibility antigen, DR beta 5 chain (Gene Name=HLA-DRB5)

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