Structure of PDB 7tns Chain D4 Binding Site BS01

Receptor Information

>7tns Chain D4 (length=428) Species: 508771 (Toxoplasma gondii ME49)

MREVISIHVGQAGIQIGNACWELFCLEHGIQPDGQMPDAFNTFFSETGAG
KHVPRCVFLDLEPTVVDEVRTGTYRHLFHPEQLISGKEDAANNFARGHYT
IGKEIVDLSLDRIRKLADNCTGLQGFLMFNAVGGGTGSGLGCLLLERLSV
DYGKKSKLNFCSWPSPQVSTAVVEPYNSVLSTHSLLEHTDVAVMLDNEAI
YDICRRNLDIERPTYTNLNRLIAQVISSLTASLRFDGALNVDVTEFQTNL
VPYPRIHFMLSSYAPIISAEKAYHEQLSVAEITNSAFEPASMMAKCDPRH
GKYMACCLMYRGDVVPKDVNAAVATIKTKRTIQFVDWCPTGFKCGINYQP
PTVVPGGDLAKVMRAVCMISNSTAIAEVFSRMDHKFDLMYAKRAFVHWYV
GEGMEEGEFSEAREDLAALEKDYEEVGI

Ligand information

>7tns Chain 13 (length=22) Species: 508771 (Toxoplasma gondii ME49)

PTLPFNAQSCYRSEYVAKPLPP

Receptor-Ligand Complex Structure

Structure summary

• PDB: 7tns Cryo-ET of Toxoplasma parasites gives subnanometer insight into tubulin-based structures.
• Resolution: 6.7 Å
• Binding residue (original residue number in PDB): Q31 E77 G81 T82 T225
• Binding residue (residue number reindexed from 1): Q31 E68 G72 T73 T216

Enzymatic activity

• Enzyme Commision number: 3.6.5.-

Gene Ontology

Molecular Function

• GO:0005200 structural constituent of cytoskeleton
• GO:0005525 GTP binding
• GO:0016787 hydrolase activity
• GO:0046872 metal ion binding

Biological Process

• GO:0000226 microtubule cytoskeleton organization
• GO:0000278 mitotic cell cycle
• GO:0007017 microtubule-based process

Cellular Component

• GO:0005737 cytoplasm
• GO:0005856 cytoskeleton
• GO:0005874 microtubule

External links

• PDB: RCSB:7tns, PDBe:7tns, PDBj:7tns
• PDBsum: 7tns
• PubMed: 35121661
• UniProt: P10873|TBA_TOXGO Tubulin alpha chain