Structure of PDB 8wqa Chain D Binding Site BS01

Receptor Information
>8wqa Chain D (length=627) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
MEGLAGYVYKAASEGKVLTLAALLLNRSESDIRYLLGYVSQQGGQRSTPL
IIAARNGHAKVVRLLLEHYRVQTQQTGTVRFDGYVIDGATALWCAAGAGH
FEVVKLLVSHGANVNHTTVTNSTPLRAACFDGRLDIVKYLVENNANISIA
NKYDNTCLMIAAYKGHTDVVRYLLEQRADPNAKAHCGATALHFAAEAGHI
DIVKELIKWRAAIVVNGHGMTPLKVAAESCKADVVELLLSHADCDRRSRI
EALELLGASFANDRENYDIIKTYHYLYLAMLERFQDGDNILEKEVLPPIH
AYGNRTECRNPQELESIRQDRDALHMEGLIVRERILGADNIDVSHPIIYR
GAVYADNMEFEQCIKLWLHALHLRQKGNRNTHKDLLRFAQVFSQMIHLNE
TVKAPDIECVLRCSVLEIEQSMNRVKNISDADVHNAMDNYECNLYTFLYL
VCISTKTQCSEEDQCKINKQIYNLIHLDPRTREGFTLLHLAVNSNTPVDD
FHTNDVCSFPNALVTKLLLDCGAEVNAVDNEGNSALHIIVQYNRPISDFL
TLHSIIISLVEAGAHTDMTNKQNKTPLDKSTTGVSEILLKTQMKMSLKCL
AARAVRANDINYQDQIPRTLEEFVGFH
Ligand information
>8wqa Chain L (length=23) Species: 9606 (Homo sapiens) [Search peptide sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
KKHSLDLLSKERELNGKLRHLSP
Receptor-Ligand Complex Structure
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PDB8wqa Cryo-EM structure of CUL2-RBX1-ELOB-ELOC-FEM1B bound with the C-degron of CCDC89 (conformation 1)
Resolution3.39 Å
Binding residue
(original residue number in PDB)		I86 W93 S122 R126 Y153 N155 I160 Y163 I348 D356 F501
Binding residue
(residue number reindexed from 1)		I86 W93 S122 R126 Y153 N155 I160 Y163 I348 D356 F501
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0005123 death receptor binding
GO:0005515 protein binding
GO:0046872 metal ion binding
GO:1990756 ubiquitin-like ligase-substrate adaptor activity
Biological Process
GO:0002070 epithelial cell maturation
GO:0006915 apoptotic process
GO:0016567 protein ubiquitination
GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process
GO:0051438 regulation of ubiquitin-protein transferase activity
GO:0060442 branching involved in prostate gland morphogenesis
GO:0060743 epithelial cell maturation involved in prostate gland development
GO:0140627 ubiquitin-dependent protein catabolic process via the C-end degron rule pathway
GO:1902041 regulation of extrinsic apoptotic signaling pathway via death domain receptors
GO:2000001 regulation of DNA damage checkpoint
Cellular Component
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005737 cytoplasm
GO:0005739 mitochondrion
GO:0005829 cytosol
GO:0031462 Cul2-RING ubiquitin ligase complex

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:8wqa, PDBe:8wqa, PDBj:8wqa
PDBsum8wqa
PubMed38670995
UniProtQ9UK73|FEM1B_HUMAN Protein fem-1 homolog B (Gene Name=FEM1B)

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