Structure of PDB 6l9m Chain D Binding Site BS01
Receptor Information
>6l9m Chain D (length=278) Species:
9606
(Homo sapiens) [
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AGPHSMRYFETAVSRPGLGEPRYISVGYVDNKEFVRFDSDAENPRYEPQA
PWMEQEGPEYWERITQIAKGQEQWFRVNLRTLLGYYNQSAGGTHTLQWMY
GCDVGSDGRLLRGYEQFAYDGCDYIALNEDLKTWTAADMAAQITRRKWEQ
AGAAEYYRAYLEGECVEWLHRYLKNGNATLLRTDSPKAHVTHHPRSKGEV
TLRCWALGFYPADITLTWQLNGEELTQDMELVETRPAGDGTFQKWASVVV
PLGKEQNYTCRVYHEGLPEPLTLRWEPP
Ligand information
>6l9m Chain F (length=9) Species:
9606
(Homo sapiens) [
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SPSYVYHQF
Receptor-Ligand Complex Structure
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PDB
6l9m
Structures suggest an approach for converting weak self-peptide tumor antigens into superagonists for CD8 T cells in cancer.
Resolution
2.6 Å
Binding residue
(original residue number in PDB)
Y7 Y45 R62 I63 I66 Q70 W73 N77 L81 Y84 W97 Y99 F116 T143 K146 W147 A152 Y155 Y156 Y159 W167 Y171
Binding residue
(residue number reindexed from 1)
Y8 Y46 R63 I64 I67 Q71 W74 N78 L82 Y85 W98 Y100 F117 T144 K147 W148 A153 Y156 Y157 Y160 W168 Y172
Enzymatic activity
Enzyme Commision number
?
External links
PDB
RCSB:6l9m
,
PDBe:6l9m
,
PDBj:6l9m
PDBsum
6l9m
PubMed
34074778
UniProt
P01897
|HA1L_MOUSE H-2 class I histocompatibility antigen, L-D alpha chain (Gene Name=H2-L)
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