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BioLiP

Structure of PDB 4w4z Chain D Binding Site BS01

Receptor Information
>4w4z Chain D (length=173) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
GNEVTLLDSRSVQGELGWIASPLEGGWEEVSIMDTPIRTYQVCNVMEPSQ
NNWLRTDWITREGAQRVYIEIKFTLRDCNSLPGVMGTCKETFNLYYYESD
NDKERFIRENQFVKIDTIAADESFTQVDIGDRIMKLNTEIRDVGPLSKKG
FYLAFQDVGACIALVSVRVFYKK
Ligand information
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB4w4z Development and Structural Analysis of a Nanomolar Cyclic Peptide Antagonist for the EphA4 Receptor.
Resolution2.41 Å
Binding residue
(original residue number in PDB)		I59 Q71 C73 N74 M76 E77 T104 R106 L111 R162 M164 C191 A193
Binding residue
(residue number reindexed from 1)		I32 Q41 C43 N44 M46 E47 T74 R76 L81 R132 M134 C161 A163
Enzymatic activity
Enzyme Commision number 2.7.10.1: receptor protein-tyrosine kinase.
External links
PDB RCSB:4w4z, PDBe:4w4z, PDBj:4w4z
PDBsum4w4z
PubMed25268696
UniProtP54764|EPHA4_HUMAN Ephrin type-A receptor 4 (Gene Name=EPHA4)

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