Structure of PDB 4w4z Chain D Binding Site BS01
Receptor Information
>4w4z Chain D (length=173) Species:
9606
(Homo sapiens) [
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GNEVTLLDSRSVQGELGWIASPLEGGWEEVSIMDTPIRTYQVCNVMEPSQ
NNWLRTDWITREGAQRVYIEIKFTLRDCNSLPGVMGTCKETFNLYYYESD
NDKERFIRENQFVKIDTIAADESFTQVDIGDRIMKLNTEIRDVGPLSKKG
FYLAFQDVGACIALVSVRVFYKK
Ligand information
>4w4z Chain H (length=12) Species:
32630
(synthetic construct) [
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APYCVYRASWSC
Receptor-Ligand Complex Structure
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PDB
4w4z
Development and Structural Analysis of a Nanomolar Cyclic Peptide Antagonist for the EphA4 Receptor.
Resolution
2.41 Å
Binding residue
(original residue number in PDB)
I59 Q71 C73 N74 M76 E77 T104 R106 L111 R162 M164 C191 A193
Binding residue
(residue number reindexed from 1)
I32 Q41 C43 N44 M46 E47 T74 R76 L81 R132 M134 C161 A163
Enzymatic activity
Enzyme Commision number
2.7.10.1
: receptor protein-tyrosine kinase.
External links
PDB
RCSB:4w4z
,
PDBe:4w4z
,
PDBj:4w4z
PDBsum
4w4z
PubMed
25268696
UniProt
P54764
|EPHA4_HUMAN Ephrin type-A receptor 4 (Gene Name=EPHA4)
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