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BioLiP

Structure of PDB 2vzy Chain D Binding Site BS01

Receptor Information
>2vzy Chain D (length=191) Species: 83332 (Mycobacterium tuberculosis H37Rv) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
SRHWPLFDLRITTPRLQLQLPTEELCDQLIDTILEEDLPFNTLSHLWQQL
AGFKRDDWSLPLAVLVDGRAVGVQALSSKDFPITRQVDSGSWLGLRYQGH
GYGTEMRAAVLYFAFAELEAQVATSRSFVDNPASIAVSRRNGYRDNGLDR
VAREGAMAEALLFRLTRDDWQRHRTVEVRVDGFDRCRPLFG
Ligand information
Ligand IDACT
InChIInChI=1S/C2H4O2/c1-2(3)4/h1H3,(H,3,4)/p-1
InChIKeyQTBSBXVTEAMEQO-UHFFFAOYSA-M
SMILES
SoftwareSMILES
ACDLabs 10.04[O-]C(=O)C
OpenEye OEToolkits 1.5.0CC(=O)[O-]
CACTVS 3.341CC([O-])=O
FormulaC2 H3 O2
NameACETATE ION
ChEMBL
DrugBankDB14511
ZINC
PDB chain2vzy Chain D Residue 1212 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB2vzy Rv0802C from Mycobacterium Tuberculosis: The First Structure of a Succinyltransferase with the Gnat Fold.
Resolution2.0 Å
Binding residue
(original residue number in PDB)		Q94 S109 G110 S111 R127 S145
Binding residue
(residue number reindexed from 1)		Q74 S89 G90 S91 R107 S125
Annotation score1
Enzymatic activity
Enzyme Commision number 2.8.1.-
Gene Ontology
Molecular Function
GO:0008999 peptide-alanine-alpha-N-acetyltransferase activity
GO:0016746 acyltransferase activity
GO:0016747 acyltransferase activity, transferring groups other than amino-acyl groups
GO:0061733 peptide-lysine-N-acetyltransferase activity
GO:1990189 peptide-serine-alpha-N-acetyltransferase activity
Biological Process
GO:0006104 succinyl-CoA metabolic process
Cellular Component
GO:0005737 cytoplasm

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:2vzy, PDBe:2vzy, PDBj:2vzy
PDBsum2vzy
PubMed18997321
UniProtP9WQG7|Y802_MYCTU Acetyl- and succinyl-CoA transferase Rv0802c (Gene Name=Rv0802c)

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