BioLiP

Structure of PDB 1x27 Chain D Binding Site BS01

Receptor Information

>1x27 Chain D (length=163) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]

NLVIALHSYEPSHDGDLGFEKGEQLRILEQSGEWWKAQSLTTGQEGFIPF
NFVAKANSLEPEPWFFKNLSRKDAERQLLAPGNTHGSFLIRESESTAGSF
SLSVRDFDQNQGEVVKHYKIRNLDNGGFYISPRITFPGLHELVRHYTNAS
DGLCTRLSRPCQT

Ligand information

>1x27 Chain L (length=6) Species: 10116 (Rattus norvegicus) [Search peptide sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]

DYDYVH

Receptor-Ligand Complex Structure

Global view

Local view

Structure summary

[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]

PDB	1x27 Molecular basis for regulation of Src by the docking protein p130Cas
Resolution	2.7 Å
Binding residue (original residue number in PDB)	R134 R154 S156 E157 S164 K179 H180 Y181 K182 R184 I193 G215
Binding residue (residue number reindexed from 1)	R71 R91 S93 E94 S101 K116 H117 Y118 K119 R121 I130 G152

Enzymatic activity

Enzyme Commision number

2.7.10.2: non-specific protein-tyrosine kinase.

External links

PDB	RCSB:1x27, PDBe:1x27, PDBj:1x27
PDBsum	1x27
PubMed	16245368
UniProt	P06239\|LCK_HUMAN Tyrosine-protein kinase Lck (Gene Name=LCK)

[Back to BioLiP]

zhanglabzhanggroup.org | +65-6601-1241 | Computing 1, 13 Computing Drive, Singapore 117417