Structure of PDB 7am2 Chain CB Binding Site BS01

Receptor Information

>7am2 Chain CB (length=135) Species: 5689 (Leishmania tarentolae) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]

EDVKEIANILSSLKVRDLCCVDVSEKTSNFDYMMFGTCEGARHIHLAAWA
VQDADKVHRISKIKRQQTDELWEVVPVGRIVVNLMVESFREEMTLERKWA
VTRSMDPLAAANAPISEGRQVKAHGLWTLTLNLQD

Ligand information

>7am2 Chain 1 (length=797) [Search RNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]

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Receptor-Ligand Complex Structure

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Structure summary

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PDB	7am2 Structure of the mature kinetoplastids mitoribosome and insights into its large subunit biogenesis.
Resolution	3.4 Å
Binding residue (original residue number in PDB)	I113 K114 R115 Q116 Q117
Binding residue (residue number reindexed from 1)	I63 K64 R65 Q66 Q67

Enzymatic activity

Enzyme Commision number

2.7.7.52: RNA uridylyltransferase.

Gene Ontology

	Molecular Function
GO:0016772	transferase activity, transferring phosphorus-containing groups
GO:0043023	ribosomal large subunit binding

	Biological Process
GO:0017148	negative regulation of translation
GO:0090071	negative regulation of ribosome biogenesis

View graph for
Molecular Function

View graph for
Biological Process

External links

PDB	RCSB:7am2, PDBe:7am2, PDBj:7am2
PDBsum	7am2
PubMed	33168716
UniProt	Q9NE59

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