Structure of PDB 9c5q Chain C Binding Site BS01

Receptor Information

>9c5q Chain C (length=775) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]

KLLLANWGLPKAVLEKYHSFGVKKMFEWQAECLLLGQVLEGKNLVYSAPT
SAGKTLVAELLILKRVLEMRKKALFILPFVSVAKEKKYYLQSLFQEVGIK
VDGYMGSTSPSRHFSSLDIAVCTIERANGLINRLIEENKMDLLGMVVVDE
LHMLGDSHRGYLLELLLTKICYITRKSASSNAVQIVGMSATLPNLELVAS
WLNAELYHTDFRPVPLLESVKVGNSIYDSSMKLVREFEPMLQVDHVVSLC
YETICDNHSVLLFCPSKKWCEKLADIIAREFYNLHHQPPVILEQKELLEV
MDQLRRLPSGLDSVLQKTVPWGVAFHHAGLTFEERDIIEGAFRQGLIRVL
AATSTLSSGVNLPARRVIIRTPIFGGRPLDILTYKQMVGRAGRKGVDTVG
ESILICKNSEKSKGIALLQGSLKPVRSCLQRREGEEVTGSMIRAILEIIV
GGVASTSQDMHTYAACTFLAASMGAIEACVMWLLENEFIQSTEKVYHPTH
LGSATLSSSLSPADTLDIFADLQRAMKGFVLENDLHILYLVTPMFEDWTT
IDWYRFFCLWEKLPTSMKRVAELVGVEEGFLARCVAAAAAAAAAAQHRQM
AIHKRFFTSLVLLDLISEVPLREINQKYGCNRGQIQSLQQSAAVYAGMIT
VFSNRLGWHNMELLLSQFQKRLTFGIQRELCDLVRVSLLNAQRARVLYAS
GFHTVADLARANIVEVEVILKNAVPFKSARKAVDEEEEAVEERRNMRTIW
RKGLTEREAAALIVEEARMILQQDL

Ligand information

>9c5q Chain D (length=14) [Search DNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]

ttttttttcccggg

Receptor-Ligand Complex Structure

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Structure summary

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PDB	9c5q Structural Basis for Pol theta-Helicase DNA Binding and Microhomology-Mediated End-Joining.
Resolution	3.1 Å
Binding residue (original residue number in PDB)	F146 V147 S176 E192 R193 R200 S346 K347 A418 T443 V757 G760 M761
Binding residue (residue number reindexed from 1)	F79 V80 S109 E125 R126 R133 S266 K267 A328 T353 V644 G647 M648

External links

PDB	RCSB:9c5q, PDBe:9c5q, PDBj:9c5q
PDBsum	9c5q
PubMed	38895274
UniProt	O75417\|DPOLQ_HUMAN DNA polymerase theta (Gene Name=POLQ)

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