BioLiP

Structure of PDB 8vat Chain C Binding Site BS01

Receptor Information

>8vat Chain C (length=370) Species: 562 (Escherichia coli) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]

GPHMSYQVLARKWRPQTFADVVGQEHVLTALANGLSLGRIHHAYLFSGTR
GVGKTSIARLLAKGLNCETGITATPCGVCDNCREIEQGRFVDLIEIDAAS
RTKVEDTRDLLDNVQYAPARGRFKVYLIDEVHMLSRHSFNALLKTLEEPP
EHVKFLLATTDPQKLPVTILSRCLQFHLKALDVEQIRHQLEHILNEEHIA
HEPRALQLLARAAEGSLRDALSLTDQAIASGDGQVSTQAVSAMLGTLDDD
QALSLVEAMVEANGERVMALINEAAARGIEWEALLVEMLGLLHRIAMVQL
SPAALGNDMAAIELRMRELARTIPPTDIQLYYQTLLIGRKELPYAPDRRM
GVEMTLLRALAFHPRMPLPE

Ligand information

>8vat Chain I (length=20) [Search DNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]

tttttttcagacaccactgc

Receptor-Ligand Complex Structure

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Structure summary

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PDB	8vat Differences between bacteria and eukaryotes in clamp loader mechanism, a conserved process underlying DNA replication.
Resolution	3.2 Å
Binding residue (original residue number in PDB)	T99 K100 V101 R105 S132 H134
Binding residue (residue number reindexed from 1)	T102 K103 V104 R108 S135 H137

Enzymatic activity

Enzyme Commision number

2.7.7.7: DNA-directed DNA polymerase.

Gene Ontology

	Molecular Function
GO:0003677	DNA binding
GO:0003887	DNA-directed DNA polymerase activity
GO:0005524	ATP binding
GO:0016887	ATP hydrolysis activity

	Biological Process
GO:0006260	DNA replication

	Cellular Component
GO:0009360	DNA polymerase III complex

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Cellular Component

PDB	RCSB:8vat, PDBe:8vat, PDBj:8vat
PDBsum	8vat
PubMed	38490435
UniProt	P06710\|DPO3X_ECOLI DNA polymerase III subunit tau (Gene Name=dnaX)