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Structure of PDB 8s8i Chain C Binding Site BS01

Receptor Information

>8s8i Chain C (length=220) Species: 284590 (Kluyveromyces lactis NRRL Y-1140)

EEKGWVPVTKLGRLVKAGKISSIEEIFLHSLPVKEFQIIDQLLPNLKDEV
MNIKPVQKQTRAGQRTRFKAVVVVGDSNGHVGLGIKTAKEVAGAIRAGII
IAKLSVIPIRRGYWGTNLGQPHSLATKTSGKCGSVSVRLIPAPRGSGIVA
SPAVKKLMQLAGVEDVYTSSTGSTRTLENTLKAAFVAIGNTYGFLTPNLW
EVQALTPSPMDVYADYATAS

Ligand information

>8s8i Chain 2 (length=1789)

uaucugguugauccugccaguagucauaugcuugucucaaagauuaagcc
augcaugucuaaguauaagcaauuuauacagugaaacugcgaauggcuca
uuaaaucaguuaucguuuauuugauaguuccuuuacuacauggauaucug
ugguaauucuagagcuaauacaugcuuaaaaucucgacccuuuggaagag
auguauuuauuagauaaaaaaucaaugucuucggacuccuugaugauuca
uaauaacuuuucgaaucgcauggccuugugcuggcgaugguucauucaaa
uuucugcccuaucaacuuucgaugguaggauaguggccuaccaugguuuc
aacggguaacggggaauaaggguucgauuccggagagggagccugagaaa
cggcuaccacauccaaggaaggcagcaggcgcgcaaauuacccaauccua
auucagggagguagugacaauaaauaacgauacagggcccauucgggucu
uguaauuggaaugaguacaauguaaauaccuuaacgaggaacaacuggag
ggcaagucuggugccagcagccgcgguaauuccagcuccaguagcguaua
uuaaaguuguugcaguuaaaaagcucguaguugaacuuugggucugguug
uccgguccgcgcgcacugguuuucaaccggaucuuuccuucuggcuaacc
uguacuccuugugggugcaggcgaaccaggacuuuuacuuugaaaaaauu
agaguguucaaagcaggcgaaagcucgaauauauuagcauggaauaaugg
aauaggacguuugguucuauuuuguugguuucuaggaccaucguaaugau
uaauagggacggucgggggcaucaguauucaauugucagaggugaaauuc
uuggauuuauugaagacuaacuacugcgaaagcauuugccaaggacguuu
ucauuaaucaagaacgaaaguuaggggaucgaagaugaucagauaccguc
guagucuuaaccauaaacuaugccgacuagggaucgggugguguuuuucu
uaugacccacucggcaccuuacgagaaaucaaagucuuuggguucugggg
ggaguauggucgcaaggcugaaacuuaaaggaauugacggaagggcacca
ccaggaguggagccugcggcuuaauuugacucaacacggggaaacucacc
agguccagacacaauaaggauugacagauugagagcucuuucuugauuuu
gugggugguggugcauggccguucuuaguugguggagugauuugucugcu
uaauugcgauaacgaacgagaccuuaaccuacuaaauaggguugcuggca
cuugccgguugacucuucuuagagggacuaucgguuucaagccgauggaa
guuugaggcaauaacaggucugugaugcccuuagacguucugggccgcac
gcgcgcuacacugacggagccagcgaguacaaccuuggccgagaggucug
gguaaucuugugaaacuccgucgugcuggggauagagcauuguaauuauu
gcucuucaacgaggaauuccuaguaagcgcaagucaucagcuugcguuga
uuacgucccugcccuuuguacacaccgcccgucgcuaguaccgauugaau
ggcuuagugaggccucaggauuugcuuagagaagggggcaacuccaucuc
agagcgaagaaucuggucaaacuuggucauuuagaggaacuaaaagucgu
aacaagguuuccguaggugaaccugcggaaggaucauua

...<<<<<...[[[[>>>>>[[[[.((((((................[[[
.[[[..<<....<<....<<..........>>...>>.>>......{{..
......[[[..{{..{{....[[[................<<.....<<.
<<<.....>>>.>>......>>........<<<<<..<<....>>..>>>
>>[...((((((......<<<<<<<.<<<....>>>..............
)))))).....]...<<<<..<<<.....>>>.>>>>....]]]...}}}
}..]]].<<<....<<<....<<<<<<<<.......>>>>>>>>>>>...
...>>>...<<<.<<<<....>>>>....>>>.}}.<<.<<<........
..>>>.>>.<.<<....>>.>...]]]]]].........<<<....<<<.
....>>>..>>>...............<<.<<<<<<.<.......>..>>
>>>>..>>......<<..<...........>..>>.........<<<<<(
(....<.<<<<.....<<..))>>.......>>>>>>>>>>..))))))]
]]].........[[[<<.......{{...[[[.{{....<<<<<<<<<<<
.<<<<..<..>....>>>>....>>>>>>>>>>>....<<<<<<......
<<.<<<.......>>>.>>......>>>>>>...<<<<<.<<.......<
<...<.......>..<<<....>>>....>>......>>.>>..>>>...
......[[[..(((((((......>>>>>>>..))))))).]]].....}
}....<<<<<<.<<...<<<<..<<<.<<<<<<.<...<<<......>>>
......>.>>>>>>.>>>.......<<....>>...>>>>..>.>>>>.>
>>...]]]...}}......<<<<<<<...<...<<<<.<.....>.>>>>
...>>>>>>>>..........<<<.<<.<<<..<<<<<<<<.<<<.....
...>>>>>>>>>>>..>>>...<<..>>>>...>>.....>>>.]]].<<
<......<<<<....>>>>....>>>..]]]]..<<<<<.<<<<<<<..<
<.<<<<<<..<<<.<<<<<<......<<........>>..........<<
<<<.<....<<<<<........<<.<<<........>>>.>>......>>
>>>...<<.<<<..<<.<<<<<<....<<<.<<<<......>>...<<<.
.....>>>...>>.>>>....<<<<<.<<..<<<<..<<<<<<<<<<<<.
...>>>>>>.>>>>>>..>>>>.>>....<<<<<<.....>>>>>>....
...>>>>>....>>>.>>>.....>>>>>>>.....>.>>>>>...>>.>
>>>.>>>.....<<<<<<<......<<.....<<<.<<<<....>>>>.>
>>....>>.......>>>>>>>......<....<<<<<<..........>
>>>>>....>.....>>>>>>....<<<<<<<<.......>>>>>>>>..
....>>...>>>>>>>>>>.>>....<..<<.<..<<<<.<<....<<<<
<<<<.<<<..<<<<..<...<<<<<<........................
..>>>>>>...>..>>>>..>>>.>>>>>>>>...>>.>>>>...>.>>.
..>.....<<<<<<<<<....>>>>>>>>>.........

Receptor-Ligand Complex Structure

Structure summary

Jmol._Canvas2D (Jmol) "jmolApplet0"[x]

Jmol._Canvas2D (Jmol) "jmolApplet1"[x]

• PDB: 8s8i Structural basis of AUC codon discrimination during translation initiation in yeast.
• Resolution: 4.3 Å
• Binding residue (original residue number in PDB): K69 K89 V91 Q92 K93 Q94 R96 A97 G98 R102 K104 S164 K166 G168 S169 R173 V184 A185 S186 Y202 T203 S205 S208 T209 R210 T211 E213 N214 K217 F229
• Binding residue (residue number reindexed from 1): K34 K54 V56 Q57 K58 Q59 R61 A62 G63 R67 K69 S129 K131 G133 S134 R138 V149 A150 S151 Y167 T168 S170 S173 T174 R175 T176 E178 N179 K182 F194

External links

• PDB: RCSB:8s8i, PDBe:8s8i, PDBj:8s8i
• PDBsum: 8s8i
• PubMed: 39193907
• UniProt: Q6CKL3

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