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Structure of PDB 8bwf Chain C Binding Site BS01

Receptor Information

>8bwf Chain C (length=79) Species: 9606 (Homo sapiens)

GPPSRVIHIRKLPIDVTEGEVISLGLPFGKVTNLLMLKGKNQAFIEMNTE
EAANTMVNYYTSVTPVLRGQPIYIQFSNH

Ligand information

>8bwf Chain c (length=12) Species: 9606 (Homo sapiens)

NQKRAQKALQVN

Receptor-Ligand Complex Structure

Structure summary

• PDB: 8bwf Rationally designed stapled peptides allosterically inhibit PTBP1-RNA-binding.
• Resolution: 2.9 Å
• Binding residue (original residue number in PDB): E72 I76 L80 K84 V85 N87 L88 K92
• Binding residue (residue number reindexed from 1): E18 I22 L26 K30 V31 N33 L34 K38

Gene Ontology

Molecular Function

• GO:0003676 nucleic acid binding
• GO:0003723 RNA binding

External links

• PDB: RCSB:8bwf, PDBe:8bwf, PDBj:8bwf
• PDBsum: 8bwf
• PubMed: 37564416
• UniProt: P26599|PTBP1_HUMAN Polypyrimidine tract-binding protein 1 (Gene Name=PTBP1)

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