BioLiP

Structure of PDB 7yxr Chain C Binding Site BS01

Receptor Information

>7yxr Chain C (length=245) Species: 32644 (unidentified) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]

EFPTLISLLEVIEPEVLASGYDSTLPDTSTRLMSTLNRLGGRQVVSAVKW
AKALPGFRNLHLDDQMTLLQYSWMSLMAFSLGWRSYKQSNGNMLCFAPDL
VINEERMQLPYMYDQCQQMLKISSEFVRLQVSYDEYLCMKVLLLLSTVPK
DGLKSQAVFDEIRMTYIKELGKAIVKRSQNWQRFYQLTKLLDSMHEMVGG
LLQFCFYTFVNKSLSVEFPEMLAEIISNQLPKFKAGSVKPLLFHQ

Ligand information

>7yxr Chain S (length=12) Species: 9606 (Homo sapiens) [Search peptide sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]

RPAILYALLSSS

Receptor-Ligand Complex Structure

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Structure summary

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PDB	7yxr The multivalency of the glucocorticoid receptor ligand-binding domain explains its manifold physiological activities.
Resolution	2.5 Å
Binding residue (original residue number in PDB)	K579 L589 M593 Q597 E755 N759
Binding residue (residue number reindexed from 1)	K52 L62 M66 Q70 E224 N228

Enzymatic activity

Enzyme Commision number

Gene Ontology

	Molecular Function
GO:0003677	DNA binding
GO:0004879	nuclear receptor activity
GO:0034056	estrogen response element binding

	Biological Process
GO:0006357	regulation of transcription by RNA polymerase II
GO:0030518	nuclear receptor-mediated steroid hormone signaling pathway

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Molecular Function

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Biological Process

PDB	RCSB:7yxr, PDBe:7yxr, PDBj:7yxr
PDBsum	7yxr
PubMed	36464162
UniProt	A0A1X8XLE9