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BioLiP

Structure of PDB 7r6t Chain C Binding Site BS01

Receptor Information
>7r6t Chain C (length=290) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
VLEQFGFPLTGTEARCYTNHALSYDQAKRVPRWVLEHISKSKIMGDADRK
HCKFKPDPNIPPTFSAFNEDYVGSGWSRGAMAPAGNNKFSSKAMAETFYL
SNIVPQDFDNNSGYWNRIEMYCRELTERFEDVWVVSGPLTLPQTRGDGKK
IVSYQVIGEDNVAVPSHLYKVILARRSSVSTEPLALGAFVVPNEAIGFQP
QLTEFQVSLQDLEKLSGLVFFPHLDRTSDIRNICSVDTCKLLDFQEFTLY
LSTRKIEGARSVLRLEKIMENLKNAEIEPDDYFMSRYEKK
Ligand information
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB7r6t Human EXOG possesses strong AP hydrolysis activity
Resolution2.9 Å
Binding residue
(original residue number in PDB)		R109 S137 R138 G145 F168 N171 S172 N176 Y310 L311 R314
Binding residue
(residue number reindexed from 1)		R49 S77 R78 G85 F108 N111 S112 N116 Y250 L251 R254
Enzymatic activity
Enzyme Commision number 3.1.30.-
Gene Ontology
Molecular Function
GO:0003676 nucleic acid binding
GO:0016787 hydrolase activity
GO:0046872 metal ion binding

View graph for
Molecular Function
External links
PDB RCSB:7r6t, PDBe:7r6t, PDBj:7r6t
PDBsum7r6t
PubMed
UniProtQ9Y2C4|EXOG_HUMAN Nuclease EXOG, mitochondrial (Gene Name=EXOG)

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