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Structure of PDB 7lp2 Chain C Binding Site BS01

Receptor Information

>7lp2 Chain C (length=33) Species: 9606 (Homo sapiens)

GLPSGWEERKDAKGRTYYVNHNNRTTTWTRPIM

Ligand information

>7lp2 Chain D (length=12) Species: 9606 (Homo sapiens)

RGPPPEYPFKGM

Receptor-Ligand Complex Structure

Structure summary

• PDB: 7lp2 Interactions between AMOT PPxY motifs and NEDD4L WW domains function in HIV-1 release.
• Resolution: 1.88 Å
• Binding residue (original residue number in PDB): R400 Y402 V404 H406 R409 T411 W413
• Binding residue (residue number reindexed from 1): R15 Y17 V19 H21 R24 T26 W28

Enzymatic activity

• Enzyme Commision number: 2.3.2.26: HECT-type E3 ubiquitin transferase.
  2.3.2.36: RING-type E3 ubiquitin transferase (cysteine targeting).

External links

• PDB: RCSB:7lp2, PDBe:7lp2, PDBj:7lp2
• PDBsum: 7lp2
• PubMed: 34284061
• UniProt: Q96PU5|NED4L_HUMAN E3 ubiquitin-protein ligase NEDD4-like (Gene Name=NEDD4L)

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