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BioLiP

Structure of PDB 6whn Chain C Binding Site BS01

Receptor Information
>6whn Chain C (length=367) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
KKKVCYYYDGDIGNYYYGQGHPMKPHRIRMTHNLLLNYGLYRKMEIYRPH
KATAEEMTKYHSDEYIKFLRSIRPDNMSEYSKQMQRFNVGEDCPVFDGLF
EFCQLSTGGSVAGAVKLNRQQTDMAVNWAGGLHHAKKSEASGFCYVNDIV
LAILELLKYHQRVLYIDIDIHHGDGVEEAFYTTDRVMTVSFHKYGEYFPG
TGDLRDIGAGKGKYYAVNFPMRDGIDDESYGQIFKPIISKVMEMYQPSAV
VLQCGADSLSGDRLGCFNLTVKGHAKCVEVVKTFNLPLLMLGGGGYTIRN
VARCWTYETAVALDCEIPNELPYNDYFEYFGPDFKLHISPSNMTNQNTPE
YMEKIKQRLFENLRMLP
Ligand information
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB6whn Anchor extension: a structure-guided approach to design cyclic peptides targeting enzyme active sites.
Resolution1.54 Å
Binding residue
(original residue number in PDB)		H33 E103 D104 H146 G154 F155 D181 H183 F210 L276 Y308
Binding residue
(residue number reindexed from 1)		H21 E91 D92 H134 G142 F143 D169 H171 F198 L264 Y296
Enzymatic activity
Enzyme Commision number 3.5.1.-
3.5.1.98: histone deacetylase.
Gene Ontology
Molecular Function
GO:0004407 histone deacetylase activity

View graph for
Molecular Function
External links
PDB RCSB:6whn, PDBe:6whn, PDBj:6whn
PDBsum6whn
PubMed34099674
UniProtQ92769|HDAC2_HUMAN Histone deacetylase 2 (Gene Name=HDAC2)

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