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Structure of PDB 5dws Chain C Binding Site BS01

Receptor Information

>5dws Chain C (length=40) Species: 9606 (Homo sapiens)

LPLGPLPPGWEKRTDSNGRVYFVNHNTRITQWEDPRSQGQ

Ligand information

>5dws Chain D (length=10) Species: 9606 (Homo sapiens)

EAPPCYMDVI

Receptor-Ligand Complex Structure

Structure summary

• PDB: 5dws Crystal Structure of ITCH WW3 domain in complex with TXNIP peptide
• Resolution: 1.65 Å
• Binding residue (original residue number in PDB): R447 Y455 V457 H459 R462 T464 Q465 W466
• Binding residue (residue number reindexed from 1): R13 Y21 V23 H25 R28 T30 Q31 W32

Enzymatic activity

• Enzyme Commision number: 2.3.2.26: HECT-type E3 ubiquitin transferase.

External links

• PDB: RCSB:5dws, PDBe:5dws, PDBj:5dws
• PDBsum: 5dws
• UniProt: Q96J02|ITCH_HUMAN E3 ubiquitin-protein ligase Itchy homolog (Gene Name=ITCH)

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