Structure of PDB 5dws Chain C Binding Site BS01
Receptor Information
>5dws Chain C (length=40) Species:
9606
(Homo sapiens) [
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LPLGPLPPGWEKRTDSNGRVYFVNHNTRITQWEDPRSQGQ
Ligand information
>5dws Chain D (length=10) Species:
9606
(Homo sapiens) [
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EAPPCYMDVI
Receptor-Ligand Complex Structure
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PDB
5dws
Crystal Structure of ITCH WW3 domain in complex with TXNIP peptide
Resolution
1.65 Å
Binding residue
(original residue number in PDB)
R447 Y455 V457 H459 R462 T464 Q465 W466
Binding residue
(residue number reindexed from 1)
R13 Y21 V23 H25 R28 T30 Q31 W32
Enzymatic activity
Enzyme Commision number
2.3.2.26
: HECT-type E3 ubiquitin transferase.
External links
PDB
RCSB:5dws
,
PDBe:5dws
,
PDBj:5dws
PDBsum
5dws
PubMed
UniProt
Q96J02
|ITCH_HUMAN E3 ubiquitin-protein ligase Itchy homolog (Gene Name=ITCH)
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