Structure of PDB 4hfz Chain C Binding Site BS01

Receptor Information
>4hfz Chain C (length=92) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
SQIPASEQETLVRPKPLLLKLLKSVGAQKDTYTMKEVLFYLGQYIMTKRL
YDAAQQHIVYCSNDLLGDLFGVPSFSVKEHRKIYTMIYRNLV
Ligand information
Receptor-Ligand Complex Structure
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PDB4hfz The structure of an MDM2-Nutlin-3a complex solved by the use of a validated MDM2 surface-entropy reduction mutant.
Resolution2.694 Å
Binding residue
(original residue number in PDB)		L54 G58 I61 M62 Y67 Q72 H73 V93 K94 H96 Y100
Binding residue
(residue number reindexed from 1)		L38 G42 I45 M46 Y51 Q56 H57 V77 K78 H80 Y84
Enzymatic activity
Enzyme Commision number 2.3.2.27: RING-type E3 ubiquitin transferase.
Gene Ontology
Biological Process
GO:0043066 negative regulation of apoptotic process
GO:0051726 regulation of cell cycle
Cellular Component
GO:0005634 nucleus

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Biological Process
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Cellular Component
External links
PDB RCSB:4hfz, PDBe:4hfz, PDBj:4hfz
PDBsum4hfz
PubMed23897459
UniProtQ00987|MDM2_HUMAN E3 ubiquitin-protein ligase Mdm2 (Gene Name=MDM2)

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