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BioLiP

Structure of PDB 4dk7 Chain C Binding Site BS01

Receptor Information
>4dk7 Chain C (length=229) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
QLTAAQELMIQQLVAAQLQCNKRPKVTPWPLDARQQRFAHFTELAIISVQ
EIVDFAKQVPGFLQLGREDQIALLKASTIEIMLLETARRYNHETECITFL
KDFTYSKDDFHRAGLQVEFINPIFEFSRAMRRLGLDDAEYALLIAINIFS
ADRPNVQEPGRVEALQQPYVEALLSYTRIKRPQDQLRFPRMLMKLVSLRT
LSSVHSEQVFALRLQDKKLPPLLSEIWDV
Ligand information
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB4dk7 Discovery of a new binding mode for a series of liver X receptor agonists.
Resolution2.45 Å
Binding residue
(original residue number in PDB)		Q280 V283 K287 R297 E298 I301 K305 L452 E455
Binding residue
(residue number reindexed from 1)		Q50 V53 K57 R67 E68 I71 K75 L222 E225
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0004879 nuclear receptor activity
Biological Process
GO:0006629 lipid metabolic process

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Molecular Function
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Biological Process
External links
PDB RCSB:4dk7, PDBe:4dk7, PDBj:4dk7
PDBsum4dk7
PubMed22406115
UniProtP55055|NR1H2_HUMAN Oxysterols receptor LXR-beta (Gene Name=NR1H2)

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