Structure of PDB 4aid Chain C Binding Site BS01

Receptor Information

>4aid Chain C (length=539) Species: 190650 (Caulobacter vibrioides CB15)

DPMFDIKRKTIEWGGKTLVLETGRIARQADGAVLATMGETVVLATAVFAK
SQKPGQDFFPLTVNYQEKTFAAGKIPGGFFKREGRPSEKETLVSRLIDRP
IRPLFVKGFKNEVQVVVTVLQHDLENDPDILGMVAASAALCLSGAPFMGP
IGAARVGWVDGAYVLNPTLDEMKESKMDLVVAGTADAVMMVESEIQELSE
EIVLGGVNFAHQQMQAVIDAIIDLAEHAAKEPFAFEPEDTDAIKAKMKDL
VGADIAAAYKIQKKQDRYEAVGAAKKKAIAAIFKELEADVVRRGILDTGL
RIDGRDVKTVRPILGEVGILPRTHGSALFTRGETQAIVVATLGTGDDEQF
IDALEGTYKESFLLHYNFPPYSVGETGRMGSPGRREIGHGKLAWRALRPM
LPTKEDFPYTIRLVSEITESNGSSSMATVCGSSLAMMDAGVPLVRPVSGI
AMGLILEQDGFAVLSDILGDEDHLGDMDFKVAGTSEGLTSLQMDIKIAGI
TPAIMEQALAQAKEGRAHILGEMNKAMDAPRADVGDFAP

Ligand information

>4aid Chain H (length=5) Species: 190650 (Caulobacter vibrioides CB15)

RGWWR

Receptor-Ligand Complex Structure

Structure summary

• PDB: 4aid Crystal Structure of Caulobacter Crescentus Polynucleotide Phosphorylase Reveals a Mechanism of RNA Substrate Channelling and RNA Degradosome Assembly.
• Resolution: 2.6 Å
• Binding residue (original residue number in PDB): V104 A143 P144 G147 F231 F233
• Binding residue (residue number reindexed from 1): V106 A145 P146 G149 F233 F235

Enzymatic activity

• Enzyme Commision number: 2.7.7.8: polyribonucleotide nucleotidyltransferase.

Gene Ontology

Molecular Function

• GO:0000175 3'-5'-RNA exonuclease activity
• GO:0000287 magnesium ion binding
• GO:0003676 nucleic acid binding
• GO:0003723 RNA binding
• GO:0004654 polyribonucleotide nucleotidyltransferase activity
• GO:0016779 nucleotidyltransferase activity
• GO:0046872 metal ion binding

Biological Process

• GO:0006396 RNA processing
• GO:0006401 RNA catabolic process
• GO:0006402 mRNA catabolic process

Cellular Component

• GO:0005737 cytoplasm
• GO:0005829 cytosol

External links

• PDB: RCSB:4aid, PDBe:4aid, PDBj:4aid
• PDBsum: 4aid
• PubMed: 22724061
• UniProt: Q9AC32|PNP_CAUVC Polyribonucleotide nucleotidyltransferase (Gene Name=pnp)