Structure of PDB 3rqe Chain C Binding Site BS01

Receptor Information
>3rqe Chain C (length=203) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
GHMRMTMEEMKNEAETTSMVSMPLYAVMYPVFNELERVNLSAAQTLRAAF
IKAEKENPGLTQDIIMKILEKKSVEVNFTESLLRMAADDVEEYMIERPEP
EFQDLNEKARALKQILSKIPDEINDRVRFLQTIKDIASAIKELLDTVNNV
RALEHQKKEFVKYSKSFSDTLKTYFKDGKAINVFVSANRLIHQTNLILQT
FKT
Ligand information
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB3rqe Molecular Recognition of Leucine-Aspartate Repeat (LD) Motifs by the Focal Adhesion Targeting Homology Domain of Cerebral Cavernous Malformation 3 (CCM3).
Resolution2.8 Å
Binding residue
(original residue number in PDB)		A135 I138 K139 K172 S175
Binding residue
(residue number reindexed from 1)		A137 I140 K141 K165 S168
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0005515 protein binding
GO:0019901 protein kinase binding
GO:0042803 protein homodimerization activity
Biological Process
GO:0001525 angiogenesis
GO:0003158 endothelium development
GO:0006915 apoptotic process
GO:0008284 positive regulation of cell population proliferation
GO:0010628 positive regulation of gene expression
GO:0010629 negative regulation of gene expression
GO:0030335 positive regulation of cell migration
GO:0032874 positive regulation of stress-activated MAPK cascade
GO:0033138 positive regulation of peptidyl-serine phosphorylation
GO:0035023 regulation of Rho protein signal transduction
GO:0035556 intracellular signal transduction
GO:0036481 intrinsic apoptotic signaling pathway in response to hydrogen peroxide
GO:0043066 negative regulation of apoptotic process
GO:0043149 stress fiber assembly
GO:0043406 positive regulation of MAP kinase activity
GO:0044319 wound healing, spreading of cells
GO:0045747 positive regulation of Notch signaling pathway
GO:0045765 regulation of angiogenesis
GO:0050821 protein stabilization
GO:0051683 establishment of Golgi localization
GO:0071902 positive regulation of protein serine/threonine kinase activity
GO:0090051 negative regulation of cell migration involved in sprouting angiogenesis
GO:0090168 Golgi reassembly
GO:0090316 positive regulation of intracellular protein transport
GO:1903358 regulation of Golgi organization
GO:1903588 negative regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis
GO:1990830 cellular response to leukemia inhibitory factor
Cellular Component
GO:0000139 Golgi membrane
GO:0005737 cytoplasm
GO:0005794 Golgi apparatus
GO:0005829 cytosol
GO:0005886 plasma membrane
GO:0070062 extracellular exosome
GO:0090443 FAR/SIN/STRIPAK complex

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:3rqe, PDBe:3rqe, PDBj:3rqe
PDBsum3rqe
PubMed21632544
UniProtQ9BUL8|PDC10_HUMAN Programmed cell death protein 10 (Gene Name=PDCD10)

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