Structure of PDB 2nzy Chain C Binding Site BS01

Receptor Information
>2nzy Chain C (length=351) Species: 210 (Helicobacter pylori) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
MFQPLLDAYVESASIEKMASKSPPPLKIAVANWWGDEEIKEFKNSVLYFI
LSQRYTITLHQNPNEFSDLVFGNPLGSARKILSYQNAKRVFYTGENESPN
FNLFDYAIGFDELDFNDRYLRMPLYYDRLHHKAESVNDTTAPYKLKDNSL
YALKKPSHCFKEKHPNLCAVVNDESDPLKRGFASFVASNPNAPIRNAFYD
ALNSIEPVTGGGSVRNTLGYNVKNKNEFLSQYKFNLCFENTQGYGYVTEK
IIDAYFSHTIPIYWGSPSVAKDFNPKSFVNVHDFKNFDEAIDYIKYLHTH
KNAYLDMLYENPLNTLDGKAYFYQNLSFKKILAFFKTILENDTIYHDNPF
I
Ligand information
Ligand IDFUC
InChIInChI=1S/C6H12O5/c1-2-3(7)4(8)5(9)6(10)11-2/h2-10H,1H3/t2-,3+,4+,5-,6+/m0/s1
InChIKeySHZGCJCMOBCMKK-SXUWKVJYSA-N
SMILES
SoftwareSMILES
CACTVS 3.341C[C@@H]1O[C@@H](O)[C@@H](O)[C@H](O)[C@@H]1O
ACDLabs 10.04OC1C(O)C(OC(O)C1O)C
OpenEye OEToolkits 1.5.0CC1C(C(C(C(O1)O)O)O)O
OpenEye OEToolkits 1.5.0C[C@H]1[C@H]([C@H]([C@@H]([C@@H](O1)O)O)O)O
CACTVS 3.341C[CH]1O[CH](O)[CH](O)[CH](O)[CH]1O
FormulaC6 H12 O5
Namealpha-L-fucopyranose;
alpha-L-fucose;
6-deoxy-alpha-L-galactopyranose;
L-fucose;
fucose
ChEMBLCHEMBL1232862
DrugBankDB04473
ZINCZINC000001532814
PDB chain2nzy Chain C Residue 4003 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB2nzy Structure and mechanism of Helicobacter pylori fucosyltransferase. A basis for lipopolysaccharide variation and inhibitor design.
Resolution2.05 Å
Binding residue
(original residue number in PDB)		G94 L124 N240 Y246 T248 E249 K250
Binding residue
(residue number reindexed from 1)		G94 L124 N240 Y246 T248 E249 K250
Annotation score1
Enzymatic activity
Enzyme Commision number 2.4.1.152: 4-galactosyl-N-acetylglucosaminide 3-alpha-L-fucosyltransferase.
Gene Ontology
Molecular Function
GO:0008417 fucosyltransferase activity
Biological Process
GO:0006486 protein glycosylation
Cellular Component
GO:0016020 membrane

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:2nzy, PDBe:2nzy, PDBj:2nzy
PDBsum2nzy
PubMed17251184
UniProtO30511|FUCT_HELPX Alpha-(1,3)-fucosyltransferase FucT (Gene Name=fucT)

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