Structure of PDB 8cav Chain B Binding Site BS01

Receptor Information
>8cav Chain B (length=858) Species: 2020 (Thermomonospora curvata) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
ATPTEQELRAELTGPVTGAGRQIHARGVWLAVDDPAFHLPRQGWKIHLSA
RPATLQETIRRMLPAVLAVPCHFKVVRSGRHLQDLNSANNHPGSIGKAVT
IYPSPEDVAPLARRLAEDLAGMAGPRICSDRRVRPDAPVYYRYGPFHPCY
DINDDGDLELVVTDPQGNTHPGAADDSFWQPHWSPDPLTGATPHPAPSDG
PAAPVLLGGRYRVVRGLTRNGKGCVYRAIDTTDNRPVIIKEARAHVNEDT
LGRDSRLRLRNERYVLHLLRDLDDVPKVIDHFRHEDREYLAITDLGALAL
GQDVAENGLYVADPAPPGRSLRALATALLELLDHVHRRGVLVRDLTPTNV
VLDDATGRPRLVDFEISHAEDPQLYGWTPGYSPPEQERDEPATVEADYYS
LGATLFYAATGLPPTWMTGDPGNHDPRRAAEVLAGRGGMSGTILGLLDPD
PARRRAAADDIRAGRFTDAPPPPPPSARQRARRLAAAIAHSLTELSRHAA
DLMSGKDFTGGLVGSPINLYRGAAGMGMELLRHDEPSRALARGLAYWTGG
FRALRNGRPGLYTGDTGIAVFIAEAGATLGDETLLKIAEPLARPVLSRIT
ATDQHTGLAGIGTGQLLLWRLTKDAGRLELADACARRLLARDLTAELQEN
PPDYADCGAVSRTLGFAHGLAGIVHFLRDHHAATGETATEAALHKGCDTL
LEHLPPLLEAARAVSAKPMHASFCQGLAGIGAALARTGRDLGADDHLQAA
REAAAACLELAPRMYALTQCCGLAGIGELFLDLCQITGDRTYAQWADRIA
DLILARAGGSPEAPVFPDTSLHGSSGGWSIGTSGVVSFLRRLGDPAAPRL
WLDPPAGT
Ligand information
>8cav Chain G (length=11) Species: 2020 (Thermomonospora curvata) [Search peptide sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
LAAIKWEAPAH
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
PDB8cav Discovery of the Lanthipeptide Curvocidin and Structural Insights into its Trifunctional Synthetase CuvL.
Resolution2.87 Å
Binding residue
(original residue number in PDB)		G213 R265 H286 F287 R288 H289
Binding residue
(residue number reindexed from 1)		G208 R260 H281 F282 R283 H284
Enzymatic activity
Enzyme Commision number 2.7.11.1: non-specific serine/threonine protein kinase.
Gene Ontology
Molecular Function
GO:0004672 protein kinase activity
GO:0004674 protein serine/threonine kinase activity
GO:0005524 ATP binding
GO:0046872 metal ion binding
Biological Process
GO:0005975 carbohydrate metabolic process
GO:0006468 protein phosphorylation
GO:0016310 phosphorylation
GO:0018105 peptidyl-serine phosphorylation
GO:0031179 peptide modification

View graph for
Molecular Function
View graph for
Biological Process
External links
PDB RCSB:8cav, PDBe:8cav, PDBj:8cav
PDBsum8cav
PubMed37014271
UniProtD1A2F7

[Back to BioLiP]