Structure of PDB 5wri Chain B Binding Site BS01

Receptor Information

>5wri Chain B (length=273) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]

AYHKDMPLIFIGGVPRSGTTLMRAMLDAHPDIRCGEETRVIPRILALKQM
WSRSSKEKIRLDEAGVTDEVLDSAMQAFLLEIIVKHGEPAPYLCNKDPFA
LKSLTYLSRLFPNAKFLLMVRDGRASVHSMISRKVTIAGFDLNSYRDCLT
KWNRAIETMYNQCMEVGYKKCMLVHYEQLVLHPERWMRTLLKFLQIPWNH
SVLHHEEMIGKAGGVSLSKVERSTDQVIKPVNVGALSKWVGKIPPDVLQD
MAVIAPMLAKLGYDPYANPPNYG

Ligand information

>5wri Chain D (length=8) Species: 32630 (synthetic construct) [Search peptide sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]

DFEDYEFD

Receptor-Ligand Complex Structure

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Structure summary

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PDB	5wri Structural basis for the broad substrate specificity of the human tyrosylprotein sulfotransferase-1.
Resolution	1.6 Å
Binding residue (original residue number in PDB)	S117 E120 R123
Binding residue (residue number reindexed from 1)	S54 E57 R60

Enzymatic activity

Enzyme Commision number

2.8.2.20: protein-tyrosine sulfotransferase.

Gene Ontology

	Molecular Function
GO:0008476	protein-tyrosine sulfotransferase activity

	Biological Process
GO:0006478	peptidyl-tyrosine sulfation

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Molecular Function

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Biological Process

External links

PDB	RCSB:5wri, PDBe:5wri, PDBj:5wri
PDBsum	5wri
PubMed	28821720
UniProt	O60507\|TPST1_HUMAN Protein-tyrosine sulfotransferase 1 (Gene Name=TPST1)

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