Structure of PDB 4yco Chain B Binding Site BS01

Receptor Information

>4yco Chain B (length=309) Species: 83333 (Escherichia coli K-12) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]

SMRVLLAPMEGVLDSLVRELLTEVNDYDLCITEFVRVVDQLLPVKVFHRI
CPELQNASRTPSGTLVRVQLLGQFPQWLAENAARAVELGSWGVDLNCGAP
SGSGGGATLLKDPELIYQGAKAMREAVPAHLPVSVKVRLGWDSGEKKFEI
ADAVQQAGATELVVHGRTKEQGYRAEHIDWQAIGDIRQRLNIPVIANGEI
WDWQSAQQCMAISGCDAVMIGRGALNIPNLSRVVKYNEPRMPWPEVVALL
QKYTRLEKQGDTGLYHVARIKQWLSYLRKEYDEATELFQHVRVLNNSPDI
ARAIQAIDI

Ligand information

>4yco Chain D (length=74) [Search RNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]

gcgcggauagcucagucgguagagcaggggauugaaaauccccguguccu
ugguucgauuccgaguccgcgcac

<<<<<<<..<<<<........>>>>.<<<<<<.....>>>>>>.....<<
<<<.......>>>>>>>>>>>>..

Receptor-Ligand Complex Structure

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Structure summary

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PDB	4yco Major reorientation of tRNA substrates defines specificity of dihydrouridine synthases.
Resolution	2.1 Å
Binding residue (original residue number in PDB)	R190 Q207
Binding residue (residue number reindexed from 1)	R187 Q204

Enzymatic activity

Enzyme Commision number

1.3.1.-

Gene Ontology

	Molecular Function
GO:0000049	tRNA binding
GO:0010181	FMN binding
GO:0016491	oxidoreductase activity
GO:0017150	tRNA dihydrouridine synthase activity
GO:0050660	flavin adenine dinucleotide binding
GO:0102262	tRNA-dihydrouridine16 synthase activity

	Biological Process
GO:0002943	tRNA dihydrouridine synthesis
GO:0008033	tRNA processing

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Molecular Function

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Biological Process

External links

PDB	RCSB:4yco, PDBe:4yco, PDBj:4yco
PDBsum	4yco
PubMed	25902496
UniProt	P33371\|DUSC_ECOLI tRNA-dihydrouridine(16) synthase (Gene Name=dusC)

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