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BioLiP

Structure of PDB 4htp Chain B Binding Site BS01

Receptor Information
>4htp Chain B (length=222) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
QTVASHVPFADLCSTLERIQKSKGRAEKIRHFREFLDSWRKFHDALHKNH
KDVTDSFYPAMRLILPQLERERMAYGIKETMLAKLYIELLNLPRDGKDAL
KLLNYRTGDFAMIAYFVLKPRCLQKGSLTIQQVNDLLDSIASNNSAKRKD
LIKKSLLQLITQSSALEQKWLIRMIIKDLKLGVSQQTIFSVFHNDAAELH
NVTTDLEKVCRQLHDPSVGLSD
Ligand information
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB4htp Structural Basis of DNA Ligase IV-Artemis Interaction in Nonhomologous End-Joining.
Resolution2.2502 Å
Binding residue
(original residue number in PDB)		V14 D18 S45 F49
Binding residue
(residue number reindexed from 1)		V7 D11 S38 F42
Enzymatic activity
Enzyme Commision number 6.5.1.1: DNA ligase (ATP).
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0003910 DNA ligase (ATP) activity
GO:0005524 ATP binding
Biological Process
GO:0006281 DNA repair
GO:0006310 DNA recombination
GO:0051103 DNA ligation involved in DNA repair

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Molecular Function
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Biological Process
External links
PDB RCSB:4htp, PDBe:4htp, PDBj:4htp
PDBsum4htp
PubMed23219551
UniProtP49917|DNLI4_HUMAN DNA ligase 4 (Gene Name=LIG4)

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