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BioLiP

Structure of PDB 3kqk Chain B Binding Site BS01

Receptor Information
>3kqk Chain B (length=436) Species: 333284 (Hepatitis C virus (isolate Con1)) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
SPPAVPQTFQVAHLHAPTGSGKSTKVPAAYAAQGYKVLVLNPSVAATLGF
GAYMSKAHGIDPNIRTGVRTITTGAPITYSTYGKFLADGGCSGGAYDIII
CDECHSTDSTTILGIGTVLDQAETAGARLVVLATATPPGSVTVPHPNIEE
VALSSTGEIPFYGKAIPIETIKGGRHLIFCHSKKKCDELAAKLSGLGLNA
VAYYRGLDVSVIPTSGDVIVVATDALMTGFTGDFDSVIDCNTCVTQTVDF
SLDPTFTIETTTVPQDAVSRSQRRGRTGRGRMGIYRFVTPGERPSGMFDS
SVLCECYDAGCAWYELTPAETSVRLRAYLNTPGLPVCQDHLEFWESVFTG
LTHIDAHFLSQTKQAGDNFPYLVAYQATVCARAQAPPPSWDQMWKCLIRL
KPTLHGPTPLLYRLGAVQNEVTTTHPITKYIMACMS
Ligand information
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB3kqk Three conformational snapshots of the hepatitis C virus NS3 helicase reveal a ratchet translocation mechanism.
Resolution2.8 Å
Binding residue
(original residue number in PDB)		P230 V232 G255 T269 G271 H369 S370 K371 Y392 R393 T411 A413 L414 V432 Q434 T448 T450 W501 Y502 N556
Binding residue
(residue number reindexed from 1)		P42 V44 G67 T81 G83 H181 S182 K183 Y204 R205 T223 A225 L226 V244 Q246 T260 T262 W313 Y314 N368
Enzymatic activity
Enzyme Commision number 2.7.7.48: RNA-directed RNA polymerase.
3.4.21.98: hepacivirin.
3.4.22.-
3.6.1.15: nucleoside-triphosphate phosphatase.
3.6.4.13: RNA helicase.
Gene Ontology
Molecular Function
GO:0004386 helicase activity
GO:0005524 ATP binding

View graph for
Molecular Function
External links
PDB RCSB:3kqk, PDBe:3kqk, PDBj:3kqk
PDBsum3kqk
PubMed20080715
UniProtQ9WMX2|POLG_HCVCO Genome polyprotein

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