Structure of PDB 2xni Chain B Binding Site BS01

Receptor Information
>2xni Chain B (length=153) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
QVEGEVQIVSTATQTFLATCINGVCWTVYHGAGTRTIASPKGPVIQMYTN
VDQDLVGWPAPQGSRSLTPCTCGSSDLYLVTRHADVIPVRRRGDSRGSLL
SPRPISYLKGSSGGPLLCPAGHAVGLFRAAVCTRGVAKAVDFIPVENLET
TMR
Ligand information
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB2xni Novel Macrocyclic Hcv Ns3 Protease Inhibitors Derived from Alpha-Amino Cyclic Boronates.
Resolution3.3 Å
Binding residue
(original residue number in PDB)		V29 E32 V33 Q34 I35 V36 S37 R62 T63 A65 W85
Binding residue
(residue number reindexed from 1)		V2 E5 V6 Q7 I8 V9 S10 R35 T36 A38 W58
Enzymatic activity
Catalytic site (original residue number in PDB) H57 D81 G137 S139
Catalytic site (residue number reindexed from 1) H30 D54 G110 S112
Enzyme Commision number 2.7.7.48: RNA-directed RNA polymerase.
3.4.21.98: hepacivirin.
3.4.22.-
3.6.1.15: nucleoside-triphosphate phosphatase.
3.6.4.13: RNA helicase.
Gene Ontology
Molecular Function
GO:0008236 serine-type peptidase activity
Biological Process
GO:0006508 proteolysis
GO:0019087 transformation of host cell by virus

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Molecular Function
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Biological Process
External links
PDB RCSB:2xni, PDBe:2xni, PDBj:2xni
PDBsum2xni
PubMed20801653
UniProtP27958|POLG_HCV77 Genome polyprotein

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