Structure of PDB 2b3r Chain B Binding Site BS01

Receptor Information
>2b3r Chain B (length=124) Species: 10090 (Mus musculus) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
GSGAVKLSVSYRNGTLFIMVMHIKDLVTEDGADPNPYVKTYLLPDTHKTS
KRKTKISRKTRNPTFNEMLVYSGYSKETLRQRELQLSVLSAESLRENFFL
GGITLPLKDFNLSKETVKWYQLTA
Ligand information
Ligand IDSO4
InChIInChI=1S/H2O4S/c1-5(2,3)4/h(H2,1,2,3,4)/p-2
InChIKeyQAOWNCQODCNURD-UHFFFAOYSA-L
SMILES
SoftwareSMILES
OpenEye OEToolkits 1.5.0[O-]S(=O)(=O)[O-]
CACTVS 3.341[O-][S]([O-])(=O)=O
ACDLabs 10.04[O-]S([O-])(=O)=O
FormulaO4 S
NameSULFATE ION
ChEMBL
DrugBankDB14546
ZINC
PDB chain2b3r Chain B Residue 305 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB2b3r Crystal structure of the C2 domain of class II phosphatidylinositide 3-kinase C2alpha.
Resolution2.3 Å
Binding residue
(original residue number in PDB)		K1457 R1461 N1492 L1493
Binding residue
(residue number reindexed from 1)		K76 R80 N111 L112
Annotation score1
Enzymatic activity
Enzyme Commision number 2.7.1.137: phosphatidylinositol 3-kinase.
2.7.1.153: phosphatidylinositol-4,5-bisphosphate 3-kinase.
2.7.1.154: phosphatidylinositol-4-phosphate 3-kinase.
External links
PDB RCSB:2b3r, PDBe:2b3r, PDBj:2b3r
PDBsum2b3r
PubMed16338929
UniProtQ61194|P3C2A_MOUSE Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit alpha (Gene Name=Pik3c2a)

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