Structure of PDB 1alh Chain B Binding Site BS01
Receptor Information
>1alh Chain B (length=446) Species:
562
(Escherichia coli) [
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MPVLENRAAQGDITAPGGARRLTGDQTAALRDSLSDKPAKNIILLIGDGM
GDSEITAARNYAEGAGGFFKGIDALPLTGQYTHYALNKKTGKPDYVTDSA
ASATAWSTGVKTYNGALGVDIHEKDHPTILEMAKAAGLATGNVSTAELQD
ATPAALVAHVTSRKCYGPSATSEKCPGNALEKGGKGSITEQLLNARADVT
LGGGAKTFAETATAGEWQGKTLREQAEARGYQLVSDAASLNSVTEANQQK
PLLGLFADGNMPVRWLGPKATYHGNIDKPAVTCTPNPQRNDSVPTLAQMT
DKAIELLSKNEKGFFLQVEGASIDKQDHAANPCGQIGETVDLDEAVQRAL
EFAKKEGNTLVIVTANHAHASQIVAPDTKAPGLTQALNTKDGAVMVMSYG
NSEEDSQEHTGSQLRIAAYGPHAANVVGLTDQTDLFYTMKAALGLK
Ligand information
Ligand ID
ZN
InChI
InChI=1S/Zn/q+2
InChIKey
PTFCDOFLOPIGGS-UHFFFAOYSA-N
SMILES
Software
SMILES
CACTVS 3.341
[Zn++]
ACDLabs 10.04
OpenEye OEToolkits 1.5.0
[Zn+2]
Formula
Zn
Name
ZINC ION
ChEMBL
CHEMBL1236970
DrugBank
DB14532
ZINC
PDB chain
1alh Chain B Residue 450 [
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Receptor-Ligand Complex Structure
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PDB
1alh
Kinetics and crystal structure of a mutant Escherichia coli alkaline phosphatase (Asp-369-->Asn): a mechanism involving one zinc per active site.
Resolution
2.5 Å
Binding residue
(original residue number in PDB)
D327 H331 H412
Binding residue
(residue number reindexed from 1)
D324 H328 H409
Annotation score
1
Enzymatic activity
Catalytic site (original residue number in PDB)
D51 S102 D153 T155 R166 E322 D327 K328 H331 N369 H370 H412
Catalytic site (residue number reindexed from 1)
D48 S99 D150 T152 R163 E319 D324 K325 H328 N366 H367 H409
Enzyme Commision number
3.1.3.1
: alkaline phosphatase.
Gene Ontology
Molecular Function
GO:0000287
magnesium ion binding
GO:0004035
alkaline phosphatase activity
GO:0004721
phosphoprotein phosphatase activity
GO:0005515
protein binding
GO:0008270
zinc ion binding
GO:0016787
hydrolase activity
GO:0016791
phosphatase activity
GO:0030613
oxidoreductase activity, acting on phosphorus or arsenic in donors
GO:0033748
hydrogenase (acceptor) activity
GO:0046872
metal ion binding
Biological Process
GO:0006470
protein dephosphorylation
Cellular Component
GO:0030288
outer membrane-bounded periplasmic space
GO:0042597
periplasmic space
View graph for
Molecular Function
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Biological Process
View graph for
Cellular Component
External links
PDB
RCSB:1alh
,
PDBe:1alh
,
PDBj:1alh
PDBsum
1alh
PubMed
7703848
UniProt
P00634
|PPB_ECOLI Alkaline phosphatase (Gene Name=phoA)
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