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BioLiP

Structure of PDB 9enf Chain A Binding Site BS01

Receptor Information
>9enf Chain A (length=254) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
KRAFDFSAHGRRHVALRIAYMGWGYQGFASQENTNNTIEEKLFEALTKTR
LVESRQTSNYHRCGRTAKGVSAFGQVISLDLRSQFPEEIRYTHILNRVLP
PDIRILAWAPVEPSFSARFSCLERTYRYFFPRADLDIVTMDYAAQKYVGT
HDFRNLCKMDVANGVINFQRTILSAQVQLVQEPFQLCQFEVTGQAFLYHQ
VRCMMAILFLIEFPLVLYDCKDQEAQEFNITHLQQLWANHAVKTHMLYSM
LQGL
Ligand information
>9enf Chain C (length=91) [Search RNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
ggcucuguggcgcaauggauagcgcauuggacuucuagcugagccuagug
uggucauucaaagguuguggguucgagucccaccagagucg
<<<<<<<..<<<<........>>>>.<<<<..<..<<<......>>>...
.>.....>>>>.....<<<<<.......>>>>>>>>>>>>.
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB9enf The molecular basis of tRNA selectivity by human pseudouridine synthase 3.
Resolution2.97 Å
Binding residue
(original residue number in PDB)		Q82 R116 A118 K119 Y276 H277
Binding residue
(residue number reindexed from 1)		Q31 R65 A67 K68 Y198 H199
Gene Ontology
Molecular Function
GO:0009982 pseudouridine synthase activity
GO:0016853 isomerase activity
GO:0160154 tRNA pseudouridine(38/39) synthase activity
Biological Process
GO:0006400 tRNA modification
GO:0008033 tRNA processing
GO:0031119 tRNA pseudouridine synthesis
GO:1990481 mRNA pseudouridine synthesis
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005829 cytosol

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:9enf, PDBe:9enf, PDBj:9enf
PDBsum9enf
PubMed38996458
UniProtQ9BZE2|PUS3_HUMAN tRNA pseudouridine(38/39) synthase (Gene Name=PUS3)

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