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BioLiP

Structure of PDB 8x1n Chain A Binding Site BS01

Receptor Information
>8x1n Chain A (length=591) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
RTLHRNEYGIASILDSYQCTAEISLADLATIFFAQFVQEATYKEVSKMVK
DALTAIEKPTGDEQSSGCLENQLPAFLEELCHEKEILEKYGHSDCCSQSE
EGRHNCFLAHKKPTPASIPLFQVPEPVTSCEAYEEDRETFMNKFIYEIAR
RHPFLYAPTILLWAARYDKIIPSCCKAENAVECFQTKAATVTKELRESSL
LNQHACAVMKNFGTRTFQAITVTKLSQKFTKVNFTEIQKLVLDVAHVHEH
CCRGDVLDCLQDGEKIMSYICSQQDTLSNKITECCKLTTLERGQCIIHAE
NDEKPEGLSPNLNRFLGDRDFNQFSSGEKNIFLASFVHEYSRRHPQLAVS
VILRVAKGYQELLEKCFQTENPLECQDKGEEELQKYIQESQALAKRSCGL
FQKLGEYYLQNAFLVAYTKKAPQLTSSELMAITRKMAATAATCCQLSEDK
LLACGEGAADIIIGHLCIRHEMTPVNPGVGQCCTSSYANRRPCFSSLVVD
ETYVPPAFSDDKFIFHKDLCQAQGVALQTMKQEFLINLVKQKPQITEEQL
EAVIADFSGLLEKCCQGQEQEVCFAEEGQKLISKTRAALGV
Ligand information
Ligand IDZN
InChIInChI=1S/Zn/q+2
InChIKeyPTFCDOFLOPIGGS-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.341[Zn++]
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Zn+2]
FormulaZn
NameZINC ION
ChEMBLCHEMBL1236970
DrugBankDB14532
ZINC
PDB chain8x1n Chain A Residue 701 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB8x1n Structural characteristics of alpha-fetoprotein, including N-glycosylation, metal ion and fatty acid binding sites.
Resolution3.31 Å
Binding residue
(original residue number in PDB)		H22 H264 H268 D280
Binding residue
(residue number reindexed from 1)		H4 H246 H250 D262
Annotation score4
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Cellular Component
GO:0005615 extracellular space

View graph for
Cellular Component
External links
PDB RCSB:8x1n, PDBe:8x1n, PDBj:8x1n
PDBsum8x1n
PubMed38678117
UniProtP02771|FETA_HUMAN Alpha-fetoprotein (Gene Name=AFP)

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