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BioLiP

Structure of PDB 8wkz Chain A Binding Site BS01

Receptor Information
>8wkz Chain A (length=467) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
QLFVSPVVFVTLGVISLLENILVIVAIAKNKNLHSPMYFFICSLAVADML
VSVSLGFETIVITLLNSTDQSFTVNIDNVIDSVICASLLASICSLLSIAV
DRYFTIFYALQYHNIMTVKRVGIIISCIWAACTVSGILFIIYSDSSAVII
CLITMFFTMLALMASLYVHMFLMARLHGIDCSFWNESYLTGSRDERKKSL
LSKFGMDEGVTFMFIGRFDRGQKGVDVLLKAIEILSSKKEFQEMRFIIIG
KGDPELEGWARSLEEKHGNVKVITEMLSREFVRELYGSVDFVIIPSYFEP
FGLVALEAMCLGAIPIASAVGGLRDIITNETGILVKAGDPGELANAILKA
LELSRSDLSKFRENCKKRAMSFSRQGANMKGAITLTILIGVFVVCWAPFF
LHLIFYISCPQNPYCVCFMSHFNLYLILIMCNSIINPLIYALRSQELRKT
FKEIICCYEFLEVLFQG
Ligand information
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB8wkz Novel Cocrystal Structures of Peptide Antagonists Bound to the Human Melanocortin Receptor 4 Unveil Unexplored Grounds for Structure-Based Drug Design.
Resolution3.3 Å
Binding residue
(original residue number in PDB)		Q43 E100 I104 D122 D126 I129 C130 I185 S188 I194 F261 H264 L265 F284 N285 L288
Binding residue
(residue number reindexed from 1)		Q1 E58 I62 D77 D81 I84 C85 I140 S143 I149 F399 H402 L403 F422 N423 L426
External links
PDB RCSB:8wkz, PDBe:8wkz, PDBj:8wkz
PDBsum8wkz
PubMed38345933
UniProtP32245|MC4R_HUMAN Melanocortin receptor 4 (Gene Name=MC4R)

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