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Structure of PDB 8v1q Chain A Binding Site BS01

Receptor Information

>8v1q Chain A (length=1097) Species: 10306 (Human alphaherpesvirus 1 strain KOS)

GPTQRHTYYSECDEFRFIAPRVLDEDAPPEKRAGVHDGHLKRAPKVYCGG
DERDVLRVGSGGFWPRRSRLWGGVDHAPAGFNPTVTVFHVYDILENVEHA
YGMRAAQFHARFMDAITPTGTVITLLGLTPEGHRVAVHVYGTRQYFYMNK
EEVDRHLQCRAPRDLCERMAAALRESPGASFRGISADHFEAEVVERTDVY
YYETRPALFYRVYVRSGRVLSYLCDNFCPAIKKYEGGVDATTRFILDNPG
FVTFGWYRLKPGRNNTLAQPRAPMAFGTSSDVEFNCTADNLAIEGGMSDL
PAYKLMCFDIECKAGGEDELAFPVAGHPEDLVIQISCLLYDLSTTALEHV
LLFSLGSCDLPESHLNELAARGLPTPVVLEFDSEFEMLLAFMTLVKQYGP
EFVTGYNIINFDWPFLLAKLTDIYKVPLDGYGRMNGRGVFRVWDIGQSHF
QKRSKIKVNGMVNIDMYGIITDKIKLSSYKLNAVAEAVLKDKKKDLSYRD
IPAYYATGPAQRGVIGEYCIQDSLLVGQLFFKFLPHLELSAVARLAGINI
TRTIYDGQQIRVFTCLLRLADQKGFILPDTQGRFRGAGRHVGYQGARVLD
PTSGFHVNPVVVFDFASLYPSIIQAHNLCFSTLSLRADAVAHLEAGKDYL
EIEVGGRRLFFVKAHVRESLLSILLRDWLAMRKQIRSRIPQSSPEEAVLL
DKQQAAIKVVCNSVYGFTGVQHGLLPCLHVAATVTTIGREMLLATREYVH
ARWAAFEQLLADFPEAADMRAPGPYSMRIIYGDTDSIFVLCRGLTAAGLT
AMGDKMASHISRALFLPPIKLECEKTFTKLLLIAKKKYIGVIYGGKMLIK
GVDLVRKNNCAFINRTSRALVDLLFYDDTVSGAAAALAERPAEEWLARPL
PEGLQAFGAVLVDAHRRITDPERDIQDFVLTAELSRHPRAYTNKRLAHLT
VYYKLMARRAQVPSIKDRIPYVIVAQTREVEETVARLAALRELDAPRKLL
VSELAEDPAYAIAHGVALNTDYYFSHLLGAACVTFKALFGNNAKITESLL
KRFIPEVWHPPDDVAARLRAAGFGAVGAGATAEETRRMLHRAFDTLA

Ligand information

>8v1q Chain P (length=26)

gaattcgagctcggtacccggggatc

Receptor-Ligand Complex Structure

Structure summary

• PDB: 8v1q Viral DNA polymerase structures reveal mechanisms of antiviral drug resistance.
• Resolution: 2.7 Å
• Binding residue (original residue number in PDB): K534 R692 D886 T887 D888 K939 Y941 K953 G954 R959 K960 E1036 S1038 R1039 Y1044 T1045 N1046 H1051 R1071
• Binding residue (residue number reindexed from 1): K475 R589 D783 T784 D785 K836 Y838 K850 G851 R856 K857 E933 S935 R936 Y941 T942 N943 H948 R968

External links

• PDB: RCSB:8v1q, PDBe:8v1q, PDBj:8v1q
• PDBsum: 8v1q
• PubMed: 39197451
• UniProt: H9E937

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