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BioLiP

Structure of PDB 8ev1 Chain A Binding Site BS01

Receptor Information
>8ev1 Chain A (length=237) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
SLALSLTADQMVSALLDAEPPILYSEYDTRPFSEASMMGLLTNLADRELV
HMINWAKRVPGFVDLTLHDQVHLLECAWLEILMIGLVWRSMEHPGKLLFA
PNLLLDRNQGKCVEGMVEIFDMLLATSSRFRMMNLQGEEFVCLKSIILLN
SGVYTFKSLEEKDHIHRVLDKITDTLIHLMAKAGLTLQQQHQRLAQLLLI
LSHIRHMSNKGMEHLYSMKCKNVVPLSDLLLEMLDAH
Ligand information
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB8ev1 Design, synthesis, biological evaluation and crystal structure determination of dual modulators of carbonic anhydrases and estrogen receptors.
Resolution1.83 Å
Binding residue
(original residue number in PDB)		I358 K362 L372 V376 D538 L539 E542 M543
Binding residue
(residue number reindexed from 1)		I53 K57 L67 V71 D228 L229 E232 M233
Enzymatic activity
Enzyme Commision number ?
External links
PDB RCSB:8ev1, PDBe:8ev1, PDBj:8ev1
PDBsum8ev1
PubMed36516582
UniProtP03372|ESR1_HUMAN Estrogen receptor (Gene Name=ESR1)

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