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BioLiP

Structure of PDB 8ebl Chain A Binding Site BS01

Receptor Information
>8ebl Chain A (length=335) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
ELACPAERSGHVAVSDGRHMFVWGGYKSNQVRGLYDFYLPREELWIYNME
TGRWKKINTEGDVPPSMSGSCAVCVDRVLYLFGGHHSRGNTNKFYMLDSR
STDRVLQWERIDCQGIPPSSKDKLGVWVYKNKLIFFGGYGYLPEDKVLGT
FEFDETSFWNSSHPRGWNDHVHILDTETFTWSQPITTGKAPSPRAAHACA
TVGNRGFVFGGRYRDARMNDLHYLNLDTWEWNELIPQGICPVGRSWHSLT
PVSSDHLFLFGGFTTDKQPLSDAWTYCISKNEWIQFNHPYTEKPRLWHTA
CASDEGEVIVFGGCANNLLVHHRAAHSNEILIFSV
Ligand information
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB8ebl E3 ligase autoinhibition by C-degron mimicry maintains C-degron substrate fidelity.
Resolution1.37 Å
Binding residue
(original residue number in PDB)		Y50 H109 K147 Y163 S185 R189 R236 R241 S269 W270 H345
Binding residue
(residue number reindexed from 1)		Y26 H85 K123 Y139 S161 R165 R212 R217 S245 W246 H321
Enzymatic activity
Enzyme Commision number ?
External links
PDB RCSB:8ebl, PDBe:8ebl, PDBj:8ebl
PDBsum8ebl
PubMed36805027
UniProtQ9Y2U9|KLDC2_HUMAN Kelch domain-containing protein 2 (Gene Name=KLHDC2)

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