BioLiP

Structure of PDB 7ztl Chain A Binding Site BS01

Receptor Information

>7ztl Chain A (length=264) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]

RQWALEDFEIGRPLGKGKFGNVYLAREKQSKFILALKVLFKAQLEKAGVE
HQLRREVEIQSHLRHPNILRLYGYFHDATRVYLILEYAPLGTVYRELQKL
SKFDEQRTATYITELANALSYCHSKRVIHRDIKPENLLLGSAGELKIADF
GWSVHAPSSRRTTLAGTLDYLPPEMIEGRMHDEKVDLWSLGVLCYEFLVG
KPPFEANTYQETYCRISRVEFTFPDFVTEGARDLISRLLKHNPSQRPMLR
EVLEHPWITANSSK

Ligand information

>7ztl Chain B (length=18) Species: 9606 (Homo sapiens) [Search peptide sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]

SEPPSWVTEMLLEKELWG

Receptor-Ligand Complex Structure

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Structure summary

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PDB	7ztl Crystal structure of a covalently linked Aurora-A-MYCN complex
Resolution	1.9 Å
Binding residue (original residue number in PDB)	K143 A172 L289 G291 L293 L296 T333 Y334 Q335 Y338
Binding residue (residue number reindexed from 1)	K18 A47 L164 G166 L168 L171 T208 Y209 Q210 Y213

Enzymatic activity

Enzyme Commision number

2.7.11.1: non-specific serine/threonine protein kinase.

Gene Ontology

	Molecular Function
GO:0004672	protein kinase activity
GO:0005524	ATP binding

	Biological Process
GO:0006468	protein phosphorylation

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Molecular Function

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Biological Process

PDB	RCSB:7ztl, PDBe:7ztl, PDBj:7ztl
PDBsum	7ztl
PubMed	36601802
UniProt	O14965\|AURKA_HUMAN Aurora kinase A (Gene Name=AURKA)