Structure of PDB 7ztl Chain A Binding Site BS01

Receptor Information
>7ztl Chain A (length=264) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
RQWALEDFEIGRPLGKGKFGNVYLAREKQSKFILALKVLFKAQLEKAGVE
HQLRREVEIQSHLRHPNILRLYGYFHDATRVYLILEYAPLGTVYRELQKL
SKFDEQRTATYITELANALSYCHSKRVIHRDIKPENLLLGSAGELKIADF
GWSVHAPSSRRTTLAGTLDYLPPEMIEGRMHDEKVDLWSLGVLCYEFLVG
KPPFEANTYQETYCRISRVEFTFPDFVTEGARDLISRLLKHNPSQRPMLR
EVLEHPWITANSSK
Ligand information
Receptor-Ligand Complex Structure
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PDB7ztl Crystal structure of a covalently linked Aurora-A-MYCN complex
Resolution1.9 Å
Binding residue
(original residue number in PDB)		K143 A172 L289 G291 L293 L296 T333 Y334 Q335 Y338
Binding residue
(residue number reindexed from 1)		K18 A47 L164 G166 L168 L171 T208 Y209 Q210 Y213
Enzymatic activity
Enzyme Commision number 2.7.11.1: non-specific serine/threonine protein kinase.
Gene Ontology
Molecular Function
GO:0004672 protein kinase activity
GO:0005524 ATP binding
Biological Process
GO:0006468 protein phosphorylation

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Molecular Function
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Biological Process
External links
PDB RCSB:7ztl, PDBe:7ztl, PDBj:7ztl
PDBsum7ztl
PubMed36601802
UniProtO14965|AURKA_HUMAN Aurora kinase A (Gene Name=AURKA)

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