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BioLiP

Structure of PDB 7y0t Chain A Binding Site BS01

Receptor Information
>7y0t Chain A (length=447) Species: 1348623 (Priestia megaterium NBRC 15308 = ATCC 14581) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
KEMPQPKTFGELKNLPLLNTDKPVQALMKIADELGEIFKFEAPGRVTRYL
SSQRLIKEACDESRFDKNLSQALKFVRDFAGDGLATSWTHEKNWKKAHNI
LLPSFSQQAMKGYHAMMVDIAVQLVQKWERLNADEHIEVPEDMTRLTLDT
IGLCGFNYRFNSFYRDQPHPFITSMVRALDEAMNKLQRAYDENKRQFQED
IKVMNDLVDKIIADRKASGEQSDDLLTHMLNGKDPETGEPLDDENIRYQI
ITFLIAGHETTSGLLSFALYFLVKNPHVLQKAAEEAARVLVDPVPSYKQV
KQLKYVGMVLNEALRLWPTAPAFSLYAKEDTVLGGEYPLEKGDELMVLIP
QLHRDKTIWGDDVEEFRPERFENPSAIPQHAFKPFGNGQRACIGQQFALH
EATLVLGMMLKHFDFEDHTNYELDIKETLTLKPEGFVVKAKSKKIPL
Ligand information
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB7y0t Crystal structure of the P450 BM3 heme domain mutant F87A in complex with N-imidazolyl-hexanoyl-L-phenylalanyl-L-phenylalanine
Resolution1.89 Å
Binding residue
(original residue number in PDB)		L20 P25 F42 R47 Y51 S72 Q73 A74 L188 A328 A330 M354
Binding residue
(residue number reindexed from 1)		L18 P23 F40 R45 Y49 S70 Q71 A72 L186 A320 A322 M346
Enzymatic activity
Enzyme Commision number 1.14.14.1: unspecific monooxygenase.
1.6.2.4: NADPH--hemoprotein reductase.
Gene Ontology
Molecular Function
GO:0004497 monooxygenase activity
GO:0005506 iron ion binding
GO:0016705 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen
GO:0020037 heme binding

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Molecular Function
External links
PDB RCSB:7y0t, PDBe:7y0t, PDBj:7y0t
PDBsum7y0t
PubMed37713467
UniProtP14779|CPXB_PRIM2 Bifunctional cytochrome P450/NADPH--P450 reductase (Gene Name=cyp102A1)

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