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BioLiP

Structure of PDB 7nhc Chain A Binding Site BS01

Receptor Information
>7nhc Chain A (length=716) Species: 88776 (Influenza A virus (A/Brevig Mission/1/1918(H1N1))) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
MEDFVRQCFNPMIVELAEKAMKEYGEDLKIETNKFAAICTHLEVCFMYSD
FHFINERGESIIVESGDPNALLKHRFEIIEGRDRTMAWTVVNSICNTTGA
EKPKFLPDLYDYKENRFIEIGVTRREVHIYYLEKANKIKSEKTHIHIFSF
TGEEMATKADYTLDEESRARIKTRLFTIRQEMASRGLWDSFRQSERGEET
IEERFEITGTMRRLADQSLPPNFSSLENFRAYVDGFEPNGYIEGKLSQMS
KEVNARIEPFLKTTPRPLRLPDGPPCSQRSKFLLMDALKLSIEDPSHEGE
GIPLYDAIKCMRTFFGWKEPNVVKPHEKGINPNYLLAWKQVLAELQDIEN
EEKIPKTKNMKKTSQLKWALGENMAPEKVDFDDCKDVSDLKQYDSDEPEL
RSLASWIQSEFNKACELTDSSWIELDEIGEDVAPIEHIASMRRNYFTAEV
SHCRATEYIMKGVYINTALLNASCAAMDDFQLIPMISKCRTKEGRRKTNL
YGFIIKGRSHLRNDTDVVNFVSMEFSLTDPRLEPHKWEKYCVLEIGDMLL
RSAIGQVSRPMFLYVRTNGTSKIKMKWGMEMRRCLLQSLQQIESMIEAES
SVKEKDMTKEFFENKSETWPIGESPKGVEEGSIGKVCRTLLAKSVFNSLY
ASPQLEGFSAESRKLLLIVQALRDNLEPGTFDLGGLYEAIEECLINDPWV
LLNASWFNSFLTHALR
Ligand information
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB7nhc Mapping inhibitory sites on the RNA polymerase of the 1918 pandemic influenza virus using nanobodies.
Resolution2.87 Å
Binding residue
(original residue number in PDB)		M477 H510 R512
Binding residue
(residue number reindexed from 1)		M477 H510 R512
Enzymatic activity
Enzyme Commision number 3.1.-.-
Gene Ontology
Molecular Function
GO:0003723 RNA binding
GO:0004519 endonuclease activity
GO:0046872 metal ion binding
Biological Process
GO:0006351 DNA-templated transcription
GO:0039523 symbiont-mediated suppression of host mRNA transcription via inhibition of RNA polymerase II activity
GO:0039694 viral RNA genome replication
GO:0075523 viral translational frameshifting
GO:0075526 cap snatching
Cellular Component
GO:0030430 host cell cytoplasm
GO:0042025 host cell nucleus

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:7nhc, PDBe:7nhc, PDBj:7nhc
PDBsum7nhc
PubMed35017564
UniProtQ3HM39|PA_I18A0 Polymerase acidic protein (Gene Name=PA)

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