Structure of PDB 7cmz Chain A Binding Site BS01
Receptor Information
>7cmz Chain A (length=217) Species:
9606
(Homo sapiens) [
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KQYIFQLSSLNPQERIDYCHLIEKLGGLVIEKQCFDPTCTHIVVGHPLRN
EKYLASVAAGKWVLHRSYLEACRTAGHFVQEEDYEWGSSSILDVLTGINV
QQRRLALAAMRWRKKIQQRQESGIVEGAFSGWKVILHVDQSREAGFKRLL
QSGGAKVLPGHSVPLFKEATHLFSDVNIAEAAAQNVYCLRTEYIADYLMQ
ESPPHVENYCLPEAISF
Ligand information
>7cmz Chain B (length=15) Species:
9606
(Homo sapiens) [
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GACFKDAEYIYPSLE
Receptor-Ligand Complex Structure
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PDB
7cmz
PHF8-promoted TOPBP1 demethylation drives ATR activation and preserves genome stability.
Resolution
1.695 Å
Binding residue
(original residue number in PDB)
Q1298 C1299 R1314 N1315 E1316 R1369 R1407 G1410 F1411 R1413 E1467 D1471 Y1484
Binding residue
(residue number reindexed from 1)
Q33 C34 R49 N50 E51 R104 R142 G145 F146 R148 E192 D196 Y209
Enzymatic activity
Enzyme Commision number
?
External links
PDB
RCSB:7cmz
,
PDBe:7cmz
,
PDBj:7cmz
PDBsum
7cmz
PubMed
33952527
UniProt
Q92547
|TOPB1_HUMAN DNA topoisomerase 2-binding protein 1 (Gene Name=TOPBP1)
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