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BioLiP

Structure of PDB 7cmz Chain A Binding Site BS01

Receptor Information
>7cmz Chain A (length=217) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
KQYIFQLSSLNPQERIDYCHLIEKLGGLVIEKQCFDPTCTHIVVGHPLRN
EKYLASVAAGKWVLHRSYLEACRTAGHFVQEEDYEWGSSSILDVLTGINV
QQRRLALAAMRWRKKIQQRQESGIVEGAFSGWKVILHVDQSREAGFKRLL
QSGGAKVLPGHSVPLFKEATHLFSDVNIAEAAAQNVYCLRTEYIADYLMQ
ESPPHVENYCLPEAISF
Ligand information
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB7cmz PHF8-promoted TOPBP1 demethylation drives ATR activation and preserves genome stability.
Resolution1.695 Å
Binding residue
(original residue number in PDB)		Q1298 C1299 R1314 N1315 E1316 R1369 R1407 G1410 F1411 R1413 E1467 D1471 Y1484
Binding residue
(residue number reindexed from 1)		Q33 C34 R49 N50 E51 R104 R142 G145 F146 R148 E192 D196 Y209
Enzymatic activity
Enzyme Commision number ?
External links
PDB RCSB:7cmz, PDBe:7cmz, PDBj:7cmz
PDBsum7cmz
PubMed33952527
UniProtQ92547|TOPB1_HUMAN DNA topoisomerase 2-binding protein 1 (Gene Name=TOPBP1)

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