Structure of PDB 6w9l Chain A Binding Site BS01

Receptor Information
>6w9l Chain A (length=249) Species: 32630 (synthetic construct) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
FPTLISLLEVIEPEVLYSGYDSTLPDTSTRLMSTLNRLGGRQVVSAVKWA
KALPGFRNLHLDDQMTLLQYSWMSLMAFSLGWRSYKQSNGNMLCFAPDLV
INEERMQLPYMYDQCQQMLKISSEFVRLQVSYDEYLCMKVLLLLSTVPKD
GLKSQAVFDEIRMTYIKELGKAIVKREGNSSQNWQRFYQLTKLLDSMHEM
VGGLLQFCFYTFVNKSLSVEFPEMLAEIISNQLPKFKAGSVKPLLFHQK
Ligand information
Receptor-Ligand Complex Structure
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PDB6w9l Disruption of a key ligand-H-bond network drives dissociative properties in vamorolone for Duchenne muscular dystrophy treatment.
Resolution1.45 Å
Binding residue
(original residue number in PDB)		V44 K48 L58 M62 E220 M221 E224
Binding residue
(residue number reindexed from 1)		V47 K51 L61 M65 E223 M224 E227
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0004879 nuclear receptor activity
GO:0034056 estrogen response element binding
Biological Process
GO:0006357 regulation of transcription by RNA polymerase II
GO:0030518 nuclear receptor-mediated steroid hormone signaling pathway

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Molecular Function
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Biological Process
External links
PDB RCSB:6w9l, PDBe:6w9l, PDBj:6w9l
PDBsum6w9l
PubMed32917814
UniProtA0A1X8XLE9

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